Outcome of complicated osteoarticular brucellosis in a tertiary care center in Saudi Arabia

To evaluate the outcome of complicated osteoarticular brucellosis. A retrospective chart review was conducted at King Abdulaziz Medical City (KAMC), in Riyadh, Saudi Arabia. All patients aged more than 14 who have been diagnosed with complicated brucellosis with osteoarticular disease between July 2...

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Published in:PloS one 2024-03, Vol.19 (3), p.e0299878-e0299878
Main Authors: Mahmoud, Ebrahim, Alaman, Areej, Alsayari, Raghad, Hakeem, Anadel, Bosaeed, Mohammad, Ibrahim, Azaheer, Algazlan, Saleh, Almanea, Abdullah, Abulaban, Ahmed A
Format: Article
Language:English
Subjects:
Adult
Aged
Biology and Life Sciences
Brucellosis
Brucellosis - complications
Brucellosis - diagnosis
Brucellosis - drug therapy
Development and progression
Diagnosis
Doxycycline - therapeutic use
Female
Humans
Male
Medicine and Health Sciences
Middle Aged
Patient outcomes
Retrospective Studies
Saudi Arabia - epidemiology
Tertiary Care Centers
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Summary:To evaluate the outcome of complicated osteoarticular brucellosis. A retrospective chart review was conducted at King Abdulaziz Medical City (KAMC), in Riyadh, Saudi Arabia. All patients aged more than 14 who have been diagnosed with complicated brucellosis with osteoarticular disease between July 2016 and December 2022 were included. A total of 82 (10.7%) patients met the criteria, with a male predominance of 66 (80.4%), and their mean age was 56.4 ± 19.3 years. A positive blood culture was found in 33 (40.2%). The most common clinical presentation was fever (57.3%). All patients received a doxycycline-based regimen except one. 62 (75.60%) patients were treated with three or more medication regimens, while 20 (24.40%) patients received two drug regimens. The mean duration of therapy was 94.2 days for two-drug therapy and 116.4 days for three-drug therapy. A total of 78 out of 82 (95.1%) cases were cured at the end of treatment. Unfavorable outcomes were documented in four cases (two relapses and two treatment failures). Neither using three drugs regimen nor longer duration of therapy was associated with better outcome. Unfavorable outcomes have been noticed to be minimal in our cohort of patients with osteoarticular brucellosis, treated mainly with a three-drug regimen and a longer duration of therapy.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0299878