3D Printing of Polysaccharide-Based Self-Healing Hydrogel Reinforced with Alginate for Secondary Cross-Linking

Three-dimensional (3D) bioprinting has been attractive for tissue and organ regeneration with the possibility of constructing biologically functional structures useful in many biomedical applications. Autonomous healing of hydrogels composed of oxidized hyaluronate (OHA), glycol chitosan (GC), and a...

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Bibliographic Details
Published in:Biomedicines 2021-09, Vol.9 (9), p.1224
Main Authors: Roh, Hyun-Ho, Kim, Hyun-Seung, Kim, Chunggoo, Lee, Kuen-Yong
Format: Article
Language:English
Subjects:
3-D printers
3D printing
Adipic acid
Alginic acid
Cartilage
Chitosan
Cytotoxicity
Fourier transforms
Gene expression
Hydrogels
Mechanical properties
polysaccharide
Polysaccharides
secondary cross-linking
self-healing hydrogel
Shear stress
Sodium
Tissue engineering
Viscoelasticity
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Summary:Three-dimensional (3D) bioprinting has been attractive for tissue and organ regeneration with the possibility of constructing biologically functional structures useful in many biomedical applications. Autonomous healing of hydrogels composed of oxidized hyaluronate (OHA), glycol chitosan (GC), and adipic acid dihydrazide (ADH) was achieved after damage. Interestingly, the addition of alginate (ALG) to the OHA/GC/ADH self-healing hydrogels was useful for the dual cross-linking system, which enhanced the structural stability of the gels without the loss of their self-healing capability. Various characteristics of OHA/GC/ADH/ALG hydrogels, including viscoelastic properties, cytotoxicity, and 3D printability, were investigated. Additionally, potential applications of 3D bioprinting of OHA/GC/ADH/ALG hydrogels for cartilage regeneration were investigated in vitro. This hydrogel system may have potential for bioprinting of a custom-made scaffold in various tissue engineering applications.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines9091224