Spontaneously occurring tumors in different wild-derived strains of hydra

• Published in: Scientific reports 2023-05, Vol.13 (1), p.7449-7449, Article 7449
• Main Authors: Boutry, Justine, Buysse, Marie, Tissot, Sophie, Cazevielle, Chantal, Hamede, Rodrigo, Dujon, Antoine M., Ujvari, Beata, Giraudeau, Mathieu, Klimovich, Alexander, Thomas, Frédéric, Tökölyi, Jácint
• Format: Article
• Language: English
• Subjects: 631/136; 631/136/2434; 631/158; 631/158/2455; 631/158/2459; 631/158/855; 631/326/421; 631/601; 631/601/1737; 631/67/1679; 631/67/70; Animal biology; Animals; Cancer; Chlamydiales; Developmental plasticity; Female; Fresh Water; Humanities and Social Sciences; Humans; Hydra; Invertebrate Zoology; Life Sciences; Male; multidisciplinary; Phenotypic plasticity; Science; Science (multidisciplinary); Senescence; Strains (organisms); Tumors; Vacuoles
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-34656-0

Hydras are freshwater cnidarians widely used as a biological model to study different questions such as senescence or phenotypic plasticity but also tumoral development. The spontaneous tumors found in these organisms have been so far described in two female lab strains domesticated years ago ( Hydra oligactis and Pelmatohydra robusta ) and the extent to which these tumors can be representative of tumors within the diversity of wild hydras is completely unknown. In this study, we examined individuals isolated from recently sampled wild strains of different sex and geographical origin, which have developed outgrowths looking like tumors. These tumefactions have common features with the tumors previously described in lab strains: are composed of an accumulation of abnormal cells, resulting in a similar enlargement of the tissue layers. However, we also found diversity within these new types of tumors. Indeed, not only females, but also males seem prone to form these tumors. Finally, the microbiota associated to these tumors is different from the one involved in the previous lineages exhibiting tumors. We found that tumorous individuals hosted yet undescribed Chlamydiales vacuoles. This study brings new insights into the understanding of tumor susceptibility and diversity in brown hydras from different origins.