Placental and Renal Pathways Underlying Pre-Eclampsia

Pre-eclampsia is a serious complication of pregnancy characterized by a state of multiorgan hypertensive disorders, with or without proteinuria and possible multiorgan dysfunction. Chronic kidney disease is an established risk factor for the development of pre-eclampsia, as angiogenic homeostasis is...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-02, Vol.25 (5), p.2741
Main Authors: Andronikidi, Paraskevi Eva, Orovou, Eirini, Mavrigiannaki, Eleftheria, Athanasiadou, Virginia, Tzitiridou-Chatzopoulou, Maria, Iatrakis, George, Grapsa, Eirini
Format: Article
Language:English
Subjects:
Achievement tests
Apoptosis
Blood pressure
Chronic kidney failure
CKD
Creatinine
Cytokines
Development and progression
Endometrium
Fetuses
Growth factors
Hypertension
kidney
Kidney diseases
Kinases
Maternal mortality
Placenta
placentation
pre-eclampsia
Preeclampsia
Pregnancy
Premature birth
Review
Risk factors
Urine
Veins & arteries
Womens health
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Summary:Pre-eclampsia is a serious complication of pregnancy characterized by a state of multiorgan hypertensive disorders, with or without proteinuria and possible multiorgan dysfunction. Chronic kidney disease is an established risk factor for the development of pre-eclampsia, as angiogenic homeostasis is altered and the maternal circulation is already hypertensive. Facing pre-eclampsia in the context of chronic kidney disease is a challenging emergency for both the mother and the fetus. The clinical features and the management of this multi-organ disorder are clearly defined in the modern literature but the underlying pathophysiologic mechanisms remain not fully elucidated. Understanding the pathophysiology that mediates the onset of pre-eclampsia itself and in synergy with chronic kidney disease is fundamental for developing prompt prevention strategies, treatment planning, and patient counseling. This review aims to summarize the main molecular mechanisms involved in the process of pre-eclampsia, with a particular focus on the role of the kidneys and hormonal pathways related to renal function in normal pregnancy and pre-eclamptic syndromes.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25052741