Cancer Therapeutic Potential and Prognostic Value of the SLC25 Mitochondrial Carrier Family: A Review

Transporters of the solute carrier family 25 (SLC25) regulate the intracellular distribution and concentration of nucleotides, amino acids, dicarboxylates, and vitamins within the mitochondrial and cytoplasmic matrices. This mechanism involves changes in mitochondrial function, regulation of cellula...

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Published in:Cancer control 2024-01, Vol.31, p.10732748241287905
Main Authors: Gao, Renzhuo, Zhou, Dan, Qiu, Xingpeng, Zhang, Jiayi, Luo, Daya, Yang, Xiaohong, Qian, Caiyun, Liu, Zhuoqi
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Humans
Mitochondria - metabolism
Mitochondrial Membrane Transport Proteins - metabolism
Mitochondrial Proteins
Neoplasms - metabolism
Neoplasms - therapy
Organic Anion Transporters
Prognosis
Review
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container_title Cancer control
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Zhou, Dan
Qiu, Xingpeng
Zhang, Jiayi
Luo, Daya
Yang, Xiaohong
Qian, Caiyun
Liu, Zhuoqi
description Transporters of the solute carrier family 25 (SLC25) regulate the intracellular distribution and concentration of nucleotides, amino acids, dicarboxylates, and vitamins within the mitochondrial and cytoplasmic matrices. This mechanism involves changes in mitochondrial function, regulation of cellular metabolism, and the ability to provide energy. In this review, important members of the SLC25 family and their pathways affecting tumorigenesis and progression are elucidated, highlighting the diversity and complexity of these pathways. Furthermore, the significant potential of the members of SLC25 as both cancer therapeutic targets and biomarkers will be emphasized.
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subjects Biomarkers, Tumor - metabolism
Humans
Mitochondria - metabolism
Mitochondrial Membrane Transport Proteins - metabolism
Mitochondrial Proteins
Neoplasms - metabolism
Neoplasms - therapy
Organic Anion Transporters
Prognosis
Review
title Cancer Therapeutic Potential and Prognostic Value of the SLC25 Mitochondrial Carrier Family: A Review
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