Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons

The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons. We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and KC...

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Bibliographic Details
Published in:Journal of neural transplantation & plasticity 2011-01, Vol.2011 (2011), p.231-238
Main Authors: Ludwig, Anastasia, Uvarov, Pavel, Pellegrino, Christophe, Thomas-Crusells, Judith, Schuchmann, Sebastian, Saarma, Mart, Airaksinen, Matti S., Rivera, Claudio
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Cells, Cultured
Early Growth Response Transcription Factors - biosynthesis
Early Growth Response Transcription Factors - physiology
GABA
Health aspects
Hippocampus - metabolism
K Cl- Cotransporters
MAP Kinase Signaling System - physiology
Mice
Mitogen-activated protein kinases
Mitogen-Activated Protein Kinases - physiology
Neurons
Neurons - metabolism
Neurturin - physiology
Organ Culture Techniques
Physiological aspects
Symporters - biosynthesis
Symporters - physiology
Up-Regulation - physiology
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Summary:The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons. We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and KCC2 was shown to be dependent on the activation of ERK1/2. Here we demonstrate that the trophic factor neurturin can also trigger Egr4 expression and upregulate KCC2 in an ERK1/2-dependent manner. These results show that Egr4 is an important component in the mechanism for trophic factor-mediated upregulation of KCC2 in immature neurons involving the activation of specific intracellular pathways common to BDNF and Neurturin.
ISSN:0792-8483
2090-5904
1687-5443
DOI:10.1155/2011/641248