Chitosan/Cyclodextrin/TPP Nanoparticles Loaded with Quercetin as Novel Bacterial Quorum Sensing Inhibitors

The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to ge...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-11, Vol.22 (11), p.1975
Main Authors: Thanh Nguyen, Hao, Goycoolea, Francisco M
Format: Article
Language:English
Subjects:
Animal health
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Antibiotics
Antimicrobial agents
Bacteria
Bioavailability
Biosensors
Captisol
Chitosan
Chitosan - chemistry
cyclodextrin
Cyclodextrins - chemistry
Drug Compounding
Drugs
E coli
E. coli Top 10
Escherichia coli - drug effects
Gelation
Gene expression
Gram-negative bacteria
Hydrophobicity
Microbial Sensitivity Tests
Nanomaterials
Nanoparticles
Particle Size
Permeability
Physicochemical properties
Polydispersity
Quercetin
Quercetin - chemistry
Quercetin - pharmacology
Quorum Sensing - drug effects
quorum sensing inhibitors
Virulence
Virulence factors
Zeta potential
β-Cyclodextrin
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Summary:The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to generate novel nanoparticles (NPs) composed of chitosan (CS), sulfo-butyl-ether-β-cyclodextrin (Captisol ) and/or pentasodium tripolyphosphate using ionotropic gelation technique, and to evaluate their potential capacity to arrest QS in bacteria. The resulting NPs were in the size range of 250-400 nm with CS and 330-600 nm with CS , had low polydispersity index (
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22111975