Relationship between Undernutrition and Anemia in Patients with Ulcerative Colitis

This study aimed to assess the relationship between malnutrition and anemia in patients with ulcerative colitis (UC). The cross-sectional retrospective study included 80 patients with UC. Body mass index and total body fat mass were derived retrospectively from bioimpedance measurements. Anemia was...

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Bibliographic Details
Published in:Gastroenterology insights 2022-12, Vol.14 (1), p.27-36
Main Authors: Uspenskiy, Yury P., Ivanov, Sergei V., Krasichkov, Alexander S., Galagudza, Michael M., Fominykh, Yulia A.
Format: Article
Language:English
Subjects:
Amino acids
Anemia
Body fat
Body mass index
Chronic illnesses
Crohn's disease
Cytokines
Hemoglobin
Hospitals
hypoproteinemia
Immunosuppressive agents
Inflammation
Inflammatory bowel disease
Iron
Laboratories
Malnutrition
Medical records
Nutritional status
Proteins
Regression analysis
Statistical analysis
ulcerative colitis
undernutrition
Variables
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Summary:This study aimed to assess the relationship between malnutrition and anemia in patients with ulcerative colitis (UC). The cross-sectional retrospective study included 80 patients with UC. Body mass index and total body fat mass were derived retrospectively from bioimpedance measurements. Anemia was diagnosed retrospectively according to WHO criteria. A binary logistic regression was performed to study the relationship between nutritional status parameters and anemia, and adjusted for demographic and disease-associated characteristics. The prevalence of anemia in the study population was 40.0%. Among all included patients, 86.3% had acute disease corresponding to S1–S3 disease behavior. In the adjusted binary logistic model, total serum protein level below 64 g/L and low body fat percentage were associated with high odds for the of development of anemia, with odds ratios of 5.1 (95% CI 1.5; 17.8; p = 0.01) and 8.5 (95% CI 1.1; 63.6; p = 0.037), respectively. The adjusted model included sex, age, disease activity, extent of gut involvement, quantity of relapses from disease onset, and treatment with immunosuppressive drugs as confounders. Hypoproteinemia and low body fat percentage were associated with anemia in patients with UC. These results suggested that undernutrition may be involved as one of the causative factors of anemia in UC.
ISSN:2036-7422
2036-7414
2036-7422
DOI:10.3390/gastroent14010003