Venom Peptide Toxins Targeting the Outer Pore Region of Transient Receptor Potential Vanilloid 1 in Pain: Implications for Analgesic Drug Development

The transient receptor potential vanilloid 1 (TRPV1) ion channel plays an important role in the peripheral nociceptive pathway. TRPV1 is a polymodal receptor that can be activated by multiple types of ligands and painful stimuli, such as noxious heat and protons, and contributes to various acute and...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-05, Vol.23 (10), p.5772
Main Authors: Hwang, Sung-Min, Jo, Youn-Yi, Cohen, Cinder Faith, Kim, Yong-Ho, Berta, Temugin, Park, Chul-Kyu
Format: Article
Language:English
Subjects:
Analgesics
Analgesics - pharmacology
Analgesics - therapeutic use
Animals
Binding sites
Body temperature
Capsaicin receptors
Chronic pain
Drug Development
Heat
Hyperthermia
ligand
Ligands
Nervous system
Pain
Pain - drug therapy
Pain perception
peptide
Peptides
Peptides - metabolism
Peptides - pharmacology
Peptides - therapeutic use
Physiology
Review
Sensors
Therapeutic targets
Toxins
Toxins, Biological
Transient receptor potential proteins
transient receptor potential vanilloid 1
TRPV Cation Channels - metabolism
Venom
Venoms - pharmacology
Venoms - therapeutic use
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Summary:The transient receptor potential vanilloid 1 (TRPV1) ion channel plays an important role in the peripheral nociceptive pathway. TRPV1 is a polymodal receptor that can be activated by multiple types of ligands and painful stimuli, such as noxious heat and protons, and contributes to various acute and chronic pain conditions. Therefore, TRPV1 is emerging as a novel therapeutic target for the treatment of various pain conditions. Notably, various peptides isolated from venomous animals potently and selectively control the activation and inhibition of TRPV1 by binding to its outer pore region. This review will focus on the mechanisms by which venom-derived peptides interact with this portion of TRPV1 to control receptor functions and how these mechanisms can drive the development of new types of analgesics.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23105772