Lipid- and polymer-based nanostructures for cancer theranostics

The relatively new field of nanotheranostics combines the advantages of in vivo diagnosis with the ability to administer treatment through a single nano-sized carrier, offering new opportunities for cancer diagnosis and therapy. Nanotheranostics has facilitated the development of nanomedicine throug...

Full description

Saved in:
Bibliographic Details
Published in:Theranostics 2012-01, Vol.2 (12), p.1117-1126
Main Authors: Luk, Brian T, Fang, Ronnie H, Zhang, Liangfang
Format: Article
Language:English
Subjects:
Animals
Humans
Lipids - therapeutic use
Liposomes - chemistry
Nanostructures - therapeutic use
Neoplasms - diagnosis
Neoplasms - drug therapy
Polymers - therapeutic use
Review
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The relatively new field of nanotheranostics combines the advantages of in vivo diagnosis with the ability to administer treatment through a single nano-sized carrier, offering new opportunities for cancer diagnosis and therapy. Nanotheranostics has facilitated the development of nanomedicine through direct visualization of drug blood circulation and biodistribution. From a clinical perspective, nanotheranostics allows therapies to be administered and monitored in real time, thus decreasing the potential of under- or over-dosing and allowing for more personalized treatment regimens. Herein, we review recent development of nanotheranostics using lipid- and polymer-based formulations, with a particular focus on their applications in cancer research. Recent advances in nanotechnology aimed to combine therapeutic molecules with imaging agents for magnetic resonance imaging, radionuclide imaging, or fluorescence imaging are discussed.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.4381