Validation of therapeutic anti-inflammatory potential of Arjuna Ksheera Paka - A traditional Ayurvedic formulation of Terminalia arjuna

Arjuna Ksheera Paka (AKP), a traditional Ayurvedic formulation of Terminalia arjuna (T. arjuna) bark powder is used for its cardioprotective effects. However, its anti-inflammatory efficacy remained unexplored. In the present study, AKP was prepared in cow milk (as per standard Ayurvedic procedure)...

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Bibliographic Details
Published in:Journal of Traditional and Complementary Medicine 2017-10, Vol.7 (4), p.414-420
Main Authors: Dube, Nivedita, Nimgulkar, Chetan, Bharatraj, Dinesh Kumar
Format: Article
Language:English
Subjects:
Anti-inflammatory
Antioxidant
Arjuna Ksheera Paka
Ayurveda
Original
Terminalia arjuna
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Summary:Arjuna Ksheera Paka (AKP), a traditional Ayurvedic formulation of Terminalia arjuna (T. arjuna) bark powder is used for its cardioprotective effects. However, its anti-inflammatory efficacy remained unexplored. In the present study, AKP was prepared in cow milk (as per standard Ayurvedic procedure) and compared with standard hydroalcoholic extract (HA) of T. arjuna. The extracts were analyzed for gross phytoconstituents levels, and their antioxidant activitywas assayed by DPPH free radical scavenging activity and inhibition of lipid peroxidation. The in vivo anti-inflammatory activity of AKP and HA was studied in carrageenan-induced hind paw biphasic edema in C57BL/6 mice (at 200, 400 and 800 mg/kg BW). The percentage extraction yield of AKP was two folds higher than HA implying that the phytocon-stituents in AKP were diluted by a factor of 0.5. The total polyphenol content of HAwas (3.8 times) higher than AKP and the antioxidant activity of HAwas also higher compared to AKP. Both the extracts, however, showed significant (p ＜ 0.05) anti-inflammatory activity in reducing paw edema in mice. The efficacy of HA was more than AKP at early phase of inflammation, whereas, in the late phase of inflammation AKP was more efficacious and equipotent to HA. Thus, regardless of low in vitro antioxidant activity, AKP exhibited potential in vivo anti-inflammatory activity. The higher efficacy of AKP could be due to the presence of milk solids. These milk solids may act as adjuvants to T. arjuna's phytoconstituents, contributing to their sustained bioavailability, leading to higher in vivo anti-inflammatory efficacy at lower drug concentrations.
ISSN:2225-4110
2225-4110
DOI:10.1016/j.jtcme.2016.11.006