The molecular biology in wound healing & non-healing wound

The development of molecular biology and other new biotechnologies helps us to recognize the wound healing and non-healing wound of skin in the past 30 years. This review mainly focuses on the molecular biology of many cytokines (including growth factors) and other molecular factors such as extracel...

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Bibliographic Details
Published in:Chinese journal of traumatology 2017-08, Vol.20 (4), p.189-193
Main Author: Qing, Chun
Format: Article
Language:English
Subjects:
Advanced glycation end products
Cell Movement
Cytokines
Cytokines - physiology
Diabetes
Extracellular Matrix - metabolism
Fibroblasts - physiology
Humans
Invited Review
Keratinocytes - physiology
Macrophages - physiology
Molecular Biology
Neutrophils - physiology
Non-healing wound
Wound healing
Wound Healing - physiology
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Summary:The development of molecular biology and other new biotechnologies helps us to recognize the wound healing and non-healing wound of skin in the past 30 years. This review mainly focuses on the molecular biology of many cytokines (including growth factors) and other molecular factors such as extracellular matrix (ECM) on wound healing. The molecular biology in cell movement such as epidermal cells in wound healing was also discussed. Moreover many common chronic wounds such as pressure ulcers, leg ulcers, diabetic foot wounds, venous stasis ulcers, etc. usually deteriorate into non-healing wounds. Therefore the molecular biology such as advanced glycation end products (AGEs) and other molecular factors in diabetes non-healing wounds were also reviewed.
ISSN:1008-1275
DOI:10.1016/j.cjtee.2017.06.001