This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment

AF is an independent and strong predictor of long-term cognitive decline. However, the mechanism for this cognitive decline is difficult to define and likely multifactorial, leading to many different hypotheses. Examples include macro- or microvascular stroke events, biochemical changes to the blood...

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Bibliographic Details
Published in:Arrhythmia & electrophysiology review 2023-01, Vol.12 (12), p.e01-e01
Main Authors: Zenger, Brian, Rizzi, Scott, Steinberg, Benjamin A, Ranjan, Ravi, Bunch, T Jared
Format: Article
Language:English
Subjects:
Alzheimers disease
Apoptosis
Atrial fibrillation
Brain
Brain research
Cardiac arrhythmia
Clinical Electrophysiology and Ablation
Cognition disorders
Cognitive ability
Dementia
Heart
Hemodynamics
Ischemia
Measurement techniques
Medical research
Medicine, Experimental
Nervous system
Oxidative stress
Physiology
Sinuses
Vitamin E
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Summary:AF is an independent and strong predictor of long-term cognitive decline. However, the mechanism for this cognitive decline is difficult to define and likely multifactorial, leading to many different hypotheses. Examples include macro- or microvascular stroke events, biochemical changes to the blood-brain barrier related to anticoagulation, or hypo-hyperperfusion events. This review explores and discusses the hypothesis that AF contributes to cognitive decline and dementia through hypo-hyperperfusion events occurring during cardiac arrhythmias. We briefly explain several brain perfusion imaging techniques and further examine the novel findings associated with changes in brain perfusion in patients with AF. Finally, we discuss the implications and areas requiring more research to further understand and treat patients with cognitive decline related to AF.
ISSN:2050-3369
2050-3377
DOI:10.15420/aer.2022.29