Discovery of Levesquamide B through Global Natural Product Social Molecular Networking

Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, is...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (22), p.7794
Main Authors: LeClair, Mary M, Maw, Zacharie A, Grunwald, Alyssa L, Kelly, Joshua R, Haltli, Bradley A, Kerr, Russell G, Cartmell, Christopher
Format: Article
Language:English
Subjects:
Amino acids
Antifungal agents
Biological Products - chemistry
Biosynthesis
Cancer
Carbon
Glucose
GNPS
Hypotheses
Isothiazolinone
levesquamide
marine natural product
Microorganisms
Natural products
Networking
Social networks
Social organization
Streptomyces
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Summary:Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, isolated and structurally elucidated via spectroscopical techniques along with the putative structures of levesquamide C and D. For masses relating to the additional three levesquamides (E-G), their complete structures remain ambiguous.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27227794