Current Status of the Diagnosis and Management of Osteoporosis

Osteoporosis has been defined as the silent disease of the 21st century, becoming a public health risk due to its severity, chronicity and progression and affecting mainly postmenopausal women and older adults. Osteoporosis is characterized by an imbalance between bone resorption and bone production...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-08, Vol.23 (16), p.9465
Main Authors: Aibar-Almazán, Agustín, Voltes-Martínez, Ana, Castellote-Caballero, Yolanda, Afanador-Restrepo, Diego Fernando, Carcelén-Fraile, María del Carmen, López-Ruiz, Elena
Format: Article
Language:English
Subjects:
Age
Aging
Bone density
Bone diseases
Bone resorption
Densitometers
Densitometry
Diagnosis
Drug development
Drug therapy
Estrogens
Fractures
lifestyle habits
Menopause
Metabolism
Osteoporosis
Pharmacology
Physical activity
Post-menopause
Public health
Regenerative medicine
Review
Womens health
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Summary:Osteoporosis has been defined as the silent disease of the 21st century, becoming a public health risk due to its severity, chronicity and progression and affecting mainly postmenopausal women and older adults. Osteoporosis is characterized by an imbalance between bone resorption and bone production. It is diagnosed through different methods such as bone densitometry and dual X-rays. The treatment of this pathology focuses on different aspects. On the one hand, pharmacological treatments are characterized by the use of anti-resorptive drugs, as well as emerging regenerative medicine treatments such as cell therapies and the use of bioactive hydrogels. On the other hand, non-pharmacological treatments are associated with lifestyle habits that should be incorporated, such as physical activity, diet and the cessation of harmful habits such as a high consumption of alcohol or smoking. This review seeks to provide an overview of the theoretical basis in relation to bone biology, the existing methods for diagnosis and the treatments of osteoporosis, including the development of new strategies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23169465