The role of progesterone in the regulation of miR-30a and miR-143 in rat models of subarachnoid hemorrhage: a study of dose-related effects

[LANGUAGE= "English"] INTRODUCTION: Brain damage in the early-period after subarachnoid hemorrhage (SAH) is a significant cause of mortality; however, cell proliferation, apoptosis, and inflammatory cascades play roles in preventing. This study aimed to determine the effect of progesterone...

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Bibliographic Details
Published in:Boğaziçi tıp dergisi 2023-01, Vol.10 (1), p.19-25
Main Author: Ari, Buse Çağla
Format: Article
Language:English
Subjects:
acute brain injury
MicroRNAs
mir-143
mir-30a
neuroprotection
progesterone
subarachnoid hemorrhage
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Summary:[LANGUAGE= "English"] INTRODUCTION: Brain damage in the early-period after subarachnoid hemorrhage (SAH) is a significant cause of mortality; however, cell proliferation, apoptosis, and inflammatory cascades play roles in preventing. This study aimed to determine the effect of progesterone on miR-30a and miR-143 expressions after SAH.METHODS: The research was conducted on 40 Sprague-Dawley rats. They were assigned to four groups: Group 1 with SAH (n=10); Group 2, SAH+8mg progesterone (n=10); Group 3, SAH+10mg progesterone (n=10); and Group 4, the controls (n=10). Experimental SAH was created by cisternal injection model. RNAs were isolated from brain tissues and miRNA expression levels were determined by Quantitative Real-Time PCR.RESULTS: There was a 176-fold and 126-fold decrease in miR-30a and miR-143 expressions of male rats with SAH (p
ISSN:2149-0287
2149-0287
DOI:10.14744/bmj.2022.87049