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Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome

Post‐exertional malaise and delayed recovery are hallmark symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Studies on repeated cardiopulmonary exercise testing (CPET) show that previous exercise negatively affects oxygen uptake (VO2) and power output (PO) in ME/CFS. Whether t...

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Bibliographic Details
Published in:Physiological reports 2019-06, Vol.7 (11), p.e14138-n/a
Main Authors: Lien, Katarina, Johansen, Bjørn, Veierød, Marit B., Haslestad, Annicke S., Bøhn, Siv K., Melsom, Morten N., Kardel, Kristin R., Iversen, Per O.
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Language:English
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Summary:Post‐exertional malaise and delayed recovery are hallmark symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Studies on repeated cardiopulmonary exercise testing (CPET) show that previous exercise negatively affects oxygen uptake (VO2) and power output (PO) in ME/CFS. Whether this affects arterial lactate concentrations ([Laa]) is unknown. We studied 18 female patients (18–50 years) fulfilling the Canadian Consensus Criteria for ME/CFS and 15 healthy females (18–50 years) who underwent repeated CPETs 24 h apart (CPET1 and CPET2) with [Laa] measured every 30th second. VO2 at peak exercise (VO2peak) was lower in patients than in controls on CPET1 (P 
ISSN:2051-817X
2051-817X
DOI:10.14814/phy2.14138