Hepatic Inflammatory Pseudotumor—Focusing on Its Heterogeneity

Hepatic inflammatory pseudotumors (IPTs) are defined as benign, non-malignant, non-metastasizing tumors characterized by the presence of myofibroblastic spindle cells, hetorogenous populations of inflammatory cells, particularly plasma cells, lymphocytes and macrophages, as well as locations of fibr...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostics (Basel) 2023-09, Vol.13 (17), p.2857
Main Authors: Kim, Soo Ryang, Kim, Soo Ki, Koma, Yu-ichiro, Sasaki, Motoko, Asai, Akira, Nishikawa, Hiroki
Format: Article
Language:English
Subjects:
Bile ducts
Care and treatment
Cholangitis
Clinics
Diagnosis
Diagnosis, Differential
differential diagnosis
Disease
Etiology
Fibroblasts
Health aspects
hepatic inflammatory pseudotumor
heterogeneity
High temperature
Inflammation
Liver cancer
Liver tumors
Lymphocytes
Mesentery
Methods
Microorganisms
Neutrophils
Pathogenesis
pathological findings
Phlebitis
Plasma
Review
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hepatic inflammatory pseudotumors (IPTs) are defined as benign, non-malignant, non-metastasizing tumors characterized by the presence of myofibroblastic spindle cells, hetorogenous populations of inflammatory cells, particularly plasma cells, lymphocytes and macrophages, as well as locations of fibrosis and necrosis without cellular anaplasia or atypical mitoses. Despite subsequent reports in the references, hepatic IPT remains difficult to diagnose; while posing major issues specifically for its differential diagnosis compared with that of other various benign diseases and malignant hepatic tumors. Histopathological findings are always a requisite for confirming the diagnosis, particularly given that the pathogenesis of IPT remains ambiguous to date. Hepatic IPT is a heterogeneous entity in terms of its clinical features, pathological findings, and pathogenesis. Once the diagnosis is confirmed, however, needless surgery such as wedge resection and lobectomy should be avoided. Here, we discuss the heterogeneity of hepatic IPT, its clinical features, pathological findings, and pathogenesis, and describe its differential diagnosis.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13172857