Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer

The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is still undetermined. The aim of this study was to analyze the expression of four lncRNA seq...

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Bibliographic Details
Published in:BMC cancer 2022-03, Vol.22 (1), p.343-343, Article 343
Main Authors: Bieńkiewicz, Jan, Romanowicz, Hanna, Szymańska, Bożena, Domańska-Senderowska, Daria, Wilczyński, Miłosz, Stepowicz, Anna, Malinowski, Andrzej, Smolarz, Beata
Format: Article
Language:English
Subjects:
Body mass index
Cancer
Causes of
Cell cycle
Cell Proliferation - genetics
Cytokines - metabolism
Endometrial cancer
Endometrial Neoplasms - genetics
Endometrium
FAM3D-AS1
Female
Gene expression
Gene Expression Regulation, Neoplastic
Genetic aspects
Genetic transcription
Genomes
Health aspects
Humans
LINC01230
LINC01315
lncRNA
Long non-coding RNA
Non-coding RNA
Oncology, Experimental
Paraffin
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Software
Tumors
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Summary:The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is still undetermined. The aim of this study was to analyze the expression of four lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 and to investigate their significance in endometrial cancer. LncRNA sequences were investigated in paraffin blocks (tumor tissue and non-malignant endometrial tissue in archival postoperative specimens) in endometrial cancer patients (Cases, n = 120) and in cancer-free controls (n = 80) using real-time PCR assay. This study revealed a lower expression of LINC01468 in endometrial cancer patients than in controls. Both LINC01468 and FAM3D-AS1 were positively correlated with Body Mass Index (BMI) in cancer-free controls. LncRNA LINC01468 may be a protective factor in development of endometrial cancer.
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-022-09426-2