Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus

• Published in: Cardiovascular diabetology 2024-04, Vol.23 (1), p.128-128, Article 128
• Main Authors: Bi, Jiao, Zheng, Mei, Li, Ke, Sun, Siwei, Zhang, Zihang, Yan, Nana, Li, Xueping
• Format: Article
• Language: English
• Subjects: Arteriosclerosis; Atherosclerosis; Blood pressure; Calcium homeostasis; Carotid arteries; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - etiology; Carotid Intima-Media Thickness; Cholesterol; Creatinine; Cross-Sectional Studies; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Doppler effect; Enzyme-linked immunosorbent assay; FGF23; Fibroblast growth factor 23; Glucose; High density lipoprotein; Homeostasis; Hospitals; Humans; Immunoassay; Klotho; Klotho protein; Medical imaging; Prospective Studies; Proteins; Regression analysis; Risk Factors; T2DM; Ultrasonic imaging; Veins & arteries
• ISSN: 1475-2840; 1475-2840
• DOI: 10.1186/s12933-024-02205-2

Compelling evidence suggests that calcium/phosphorus homeostasis-related parameters may be linked to diabetes mellitus and cardiovascular events. However, few studies have investigated the association of fibroblast growth factor 23 (FGF23), α-klotho and FGF23/α-klotho ratio with atherosclerosis in patients with type 2 diabetes mellitus (T2DM). This study was designed to evaluate whether FGF23, α-klotho and FGF23/α-klotho ratio are associated with T2DM and further to explore the relationships between these three factors and atherosclerosis in Chinese patients with T2DM. Serum FGF23 and α-klotho levels were measured via an enzyme-linked immunosorbent assay (ELISA) kit, and the carotid intima-media thickness (CIMT) was assessed via high-resolution color Doppler ultrasonography. The associations of serum FGF23, α-klotho and FGF23/α-klotho ratio with atherosclerosis in T2DM patients were evaluated using multivariable logistic regression models. This cross-sectional study involved 403 subjects (207 with T2DM and 196 without T2DM), 41.7% of the patients had atherosclerosis, and 67.2% of the carotid intima were thickened to a thickness greater than 0.9 mm. Compared with those in the lowest tertile, higher tertiles of FGF23 levels and FGF23/α-klotho ratio were positively associated with T2DM after adjusting for covariates, and serum α-klotho concentration was inversely correlated with T2DM (all P values