Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

The myocardial infarction is the main cause of morbidity and mortality in cardiovascular diseases around the world. Although the timely and complete reperfusion via Percutaneous Coronary Intervention (PCI) or thrombolysis have distinctly decreased the mortality of myocardial infarction, reperfusion...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiothoracic surgery 2021-05, Vol.16 (1), p.1-140, Article 140
Main Authors: Huang, Fuwen, Mai, Jingting, Chen, Jingwei, He, Yinying, Chen, Xiaojun
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Biomarkers
Biosynthesis
Cardiac arrhythmia
Cardiomyocytes
Cardiovascular diseases
Coding
Cytoplasm
Enzymes
Gene expression
Genomes
Health aspects
Heart attack
Heart failure
Heart function
Homeostasis
Hypoxia
Injuries
Ischemia
Kinases
MicroRNA
miRNA
Molecular mechanisms
Molecular modelling
Morbidity
Mortality
Myocardial infarction
Myocardial ischemia
Myocardial ischemia-reperfusion-injury
Non-coding RNA
Non-coding RNAs (ncRNAs)
Oxidative stress
Phagocytosis
Physiological aspects
Physiology
Proteins
Reperfusion
Review
Reviews
RNA polymerase
Thrombolysis
Transluminal angioplasty
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The myocardial infarction is the main cause of morbidity and mortality in cardiovascular diseases around the world. Although the timely and complete reperfusion via Percutaneous Coronary Intervention (PCI) or thrombolysis have distinctly decreased the mortality of myocardial infarction, reperfusion itself may lead to supererogatory irreversible myocardial injury and heart function disorders, namely ischemia-reperfusion (I/R) injury. Extensive studies have indicated that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play important roles in the progress of myocardial I/R injury, which is closely correlative with cardiomyocytes autophagy. Moreover, autophagy plays an important role in maintaining homeostasis and protecting cells in the myocardial ischemia reperfusion and cardiomyocyte hypoxia-reoxygenation (H/R) progress. In this review, we first introduced the biogenesis and functions of ncRNAs, and subsequently summarized the roles and relevant molecular mechanisms of ncRNAs regulating autophagy in myocardial I/R injury. We hope that this review in addition to develop a better understanding of the physiological and pathological roles of ncRNAs, can also lay a foundation for the therapies of myocardial I/R injury, and even for other related cardiovascular diseases.
ISSN:1749-8090
1749-8090
DOI:10.1186/s13019-021-01524-9