Inflammatory bowel diseases in Tamil Nadu: A survey of demographics, clinical profile, and practices

• Published in: JGH open 2021-11, Vol.5 (11), p.1306-1313
• Main Authors: Yewale, Rohan V, Natarajan, Kartik, Ubal Dhus, Jeyaraj, Parameswaran, Sarojini Ashok, Palaniswamy, Kallipatti, Babu Vinish, Doraisamy, Somasundaram, Aravindh, Ramakrishnan, Arulraj, Karmegam, Sibithooran, Arun, Ramaswamy Saraswathy, Manmohan, Ujjani Shankaraiah, Mahadevan, Balakrishnan, Harri Prasad, Baskkaran, Chandrasekar, Toguluva Seshadri, Gokul, Bollu Janakan, Dutta, Amit, Joseph, Anjilivelil Joseph, Venkatraman, Jayanthi, Ganesh, Panchapakesan, Shanmuganathan, Subramanyam, Alagammai, Palaniappan L, Ramasubramanian, Ramalingam, Venkatakrishnan, Leelakrishnan, Ganesan, Ramamoorthi, Arun, Arunachalam, Srinivas, Sankaranarayanan, Kannan, Mariappan, Revathy, M Shanmugam, Sathiyasekaran, Malathi, Sarangapani, Arulprakash, Rajesh, Natrajan, Arulselvan, Velusamy, Aravind, Arumugam, Premkumar, Karunakaran, Kavitha, Sampath, Varadarajulu, Hema Vijayalakshmi, Manimaran, Murugesan, Basumani, Pandurangan, Murali, Ananthavadivelu, Ramakrishna, Balakrishnan Siddartha
• Format: Article
• Language: English
• Subjects: Age; Crohn's disease; Demography; Disease; Epidemiology; Family medical history; Gastroenterology; Genotype & phenotype; Health risk assessment; Hospitals; Inflammatory bowel disease; Medical schools; Original; Patients; pediatric inflammatory bowel disease; Pediatrics; Questionnaires; ulcerative colitis
• ISSN: 2397-9070; 2397-9070
• DOI: 10.1002/jgh3.12673

Background Inflammatory bowel disease (IBD) is increasingly diagnosed in South Asia. This survey by the Tamil Nadu Chapter of the Indian Society of Gastroenterology (TNISG) documents the demography, clinical profile, and therapeutic practices related to IBD in Tamil Nadu. Methods TNISG members from 32 institutions completed an online cross‐sectional questionnaire on IBD patients from March 2020 to January 2021. Results Of 1295 adult IBD patients, 654 had Crohn's disease (CD), 499 ulcerative colitis (UC), and 42 IBD‐unclassified (IBD‐U). CD and UC showed a unimodal age distribution. A total of 55% were graduates or postgraduates. A positive family history was noted in 30, other risk factors were uncommon. In CD, the pattern of involvement was ileocolonic (42.8%), ileal (34.7%), colonic (18.9%), and upper gastrointestinal (3.5%); while in UC, disease was characterized as extensive (44.9%), left‐sided (41.7%), or proctitis (13.4%). Perineal disease, perianal fistulae, and bowel obstruction were noted in 4.3, 14.0, and 23.5%, respectively, of CD. The most widely used drugs were mesalamine, azathioprine, and corticosteroids. Surgery was undertaken in 141 patients with CD and 23 patients with UC. Of the 138 patients with pediatric IBD (≤16 years), 23 were characterized as very early onset IBD (VEO‐IBD), 27 as early‐onset, and 88 as adolescent IBD. VEO‐IBD were more likely to have a positive family history of IBD and were more likely to have perineal disease and to have the IBD‐U phenotype. Among pediatric IBD patients, corticosteroids, mesalamine, and azathioprine were the most commonly used medications, while 25 pediatric patients received biologics. Conclusion This study provides important information on demography, clinical profile, and treatment practices of IBD in India. Regional differences in inflammatory bowel disease (IBD) profile inform our understanding of the disease as well as prevention, and health planning. This study provides a snapshot of IBD presentation and practices in India at a time when the country is in the second of four phases of IBD transition. The apparently mild nature of IBD, the consequent widespread use of mesalamine, and the association of Crohn's disease with higher levels of education, compared to ulcerative colitis, are of notable interest.