BRCA Associated Protein-1 Immuno-Histochemical Stain in Diagnosis of Malignant Mesothelioma

Objective: To differentiate malignant mesothelioma from benign mesothelial proliferations and other histological mimickers such as adenocarcinoma and squamous cell carcinoma, utilizing BRCA Associated protein1 (BAP1) immune-histochemical stain. Study Design: Retrospective longitudinal study. Place a...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2023-08, Vol.73 (4), p.1045-1049
Main Authors: Sarwar, Saud, Mushtaq, Sajid, Hameed, Maryam, Hassan, Usman, Maqbool, Hina
Format: Article
Language:English
Subjects:
BAP1
Biomarkers
Biopsy
Breast cancer
Data analysis
Diagnosis
Diagnostic tests
Immunohistochemistry
Malignant mesothelioma
Mesothelioma
Metastasis
Morphology
Oncology
Prognosis
Stains & staining
Tumors
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Summary:Objective: To differentiate malignant mesothelioma from benign mesothelial proliferations and other histological mimickers such as adenocarcinoma and squamous cell carcinoma, utilizing BRCA Associated protein1 (BAP1) immune-histochemical stain. Study Design: Retrospective longitudinal study. Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore Pakistan, from 2015 to 2020. Methodology: We examined BAP1 IHC expression in 82 cases, including 56 malignant mesotheliomas, 12 Adenocarcinomas, and 14 Squamous cell carcinomas. Fifty-six malignant mesotheliomas included 49 epithelioid, 6 Biphasic and one sarcomatoid subtype. Loss of expression was established for cases showing complete loss of nuclear staining. Results: Of 56 malignant mesotheliomas, 38(67.85%) showed loss of BAP1 expression, whereas 18(32.14%) showed retained expression. Of 12 adenocarcinoma cases, 10(83.33%) showed retained expression. Similarly, out of 14 squamous cell carcinomas, 12(85.71%) showed retained expression. Conclusion: Loss of nuclear expression of BAP1 IHC serves as a valuable diagnostic ancillary tool in distinguishing malignant mesothelioma from its histological mimickers.Keywords: BAP1, Immunohistochemistry, Malignant mesothelioma.
ISSN:0030-9648
2411-8842
DOI:10.51253/pafmj.v73i4.6122