Outcomes of Allogeneic Stem Cell Transplant in Chronic Myeloid Leukaemia - A Single-Centre Experience from Pakistan

Objective: To determine indications and outcomes of stem cell transplant in Chronic Myeloid Leukemia in a tertiary care centre in Pakistan.  Study Design: Retrospective longitudinal study Place and Duration of Study: Armed Forces Bone Marrow Transplant Center, Rawalpindi Pakistan, from Jan 2002 to J...

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Published in:Pakistan Armed Forces medical journal 2023-08, Vol.73 (4), p.964-967
Main Authors: Rehman, Jehanzeb, Hussain, Fayyaz, Chaudhry, Qamar un Nisa, Mehmood, Syed Kamran, Khan, Mehreen Ali, Shahbaz, Nighat
Format: Article
Language:English
Subjects:
Age
Analysis
Bone marrow
Bone marrow transplantation
Chemotherapy
Chronic myeloid leukaemia (CML)
Conditioning regimen
Data analysis
Developing countries
Health care access
Kinases
LDCs
Leukemia
Medical research
Medicine, Experimental
Mucositis
Nilotinib
Remission (Medicine)
Stem cell transplantation
Stem cells
Survival analysis
Transplantation
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Summary:Objective: To determine indications and outcomes of stem cell transplant in Chronic Myeloid Leukemia in a tertiary care centre in Pakistan.  Study Design: Retrospective longitudinal study Place and Duration of Study: Armed Forces Bone Marrow Transplant Center, Rawalpindi Pakistan, from Jan 2002 to Jan 2019. Methodology: Retrospective analysis of all the patients who had undergone transplants for chronic myeloid leukaemia at our centre from 2002 to 2019 was done. Cases enrolled included patients of both genders and any age for whom data related to disease status and follow-up post-transplant was available. Patients with incomplete records and follow-ups were excluded from the study. Results: Out of 73 patients, data from 53 patients was analyzed. At a median follow-up of 40 months, overall survival was 72%. Survival in patients 40 years (50%). Among the three conditioning regimens, Bu16Cy120 was the most commonly used (n=35, 66%) and had better overall survival (n=29, 83%) though statistical significance could not be established (p=0.172). Conclusion: In addition to the established indications of resistance or intolerance to tyrosine kinase inhibitors for bone marrow transplant in CML, the non-availability/ affordability, young age, and lack of access to novel drugs can be included in underdeveloped countries like Pakistan.
ISSN:0030-9648
2411-8842
DOI:10.51253/pafmj.v73i4.6857