Exploiting human memory B cell heterogeneity for improved vaccine efficacy

The major goal in vaccination is establishment of long-term, prophylactic humoral memory to a pathogen. Two major components to long-lived humoral memory are plasma cells for the production of specific immunoglobulin and memory B cells that survey for their specific antigen in the periphery for late...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2011-01, Vol.2, p.77-77
Main Authors: Pauli, Noel T, Henry Dunand, Carole J, Wilson, Patrick C
Format: Article
Language:English
Subjects:
Anthrax
antibody
B cell
immunoglobulin
Immunology
influenza
Vaccine
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The major goal in vaccination is establishment of long-term, prophylactic humoral memory to a pathogen. Two major components to long-lived humoral memory are plasma cells for the production of specific immunoglobulin and memory B cells that survey for their specific antigen in the periphery for later affinity maturation, proliferation, and differentiation. The study of human B cell memory has been aided by the discovery of a general marker for B cell memory, expression of CD27; however, new data suggests the existence of CD27⁻ memory B cells as well. These recently described non-canonical memory populations have increasingly pointed to the heterogeneity of the memory compartment. The novel B memory subsets in humans appear to have unique origins, localization, and functions compared to what was considered to be a "classical" memory B cell. In this article, we review the known B cell memory subsets, the establishment of B cell memory in vaccination and infection, and how understanding these newly described subsets can inform vaccine design and disease treatment.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2011.00077