A novel Non-rodent animal model of hydrochloric acid-induced acute and chronic lung injury

Hydrochloric acid is one of the most prevalent and hazardous chemicals. Accidental spills occur in industrial plants or during transportation. Exposure to HCl can induce severe health impairment, including acute and chronic pulmonary diseases. We have previously described the molecular, structural,...

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Bibliographic Details
Published in:Respiratory research 2024-10, Vol.25 (1), p.390-11, Article 390
Main Authors: Solopov, Pavel A, Biancatelli, Ruben Manuel Luciano Colunga, Day, Tierney, Dimitropoulou, Christiana, Catravas, John D
Format: Article
Language:English
Subjects:
Acute Lung Injury - chemically induced
Acute Lung Injury - metabolism
Acute Lung Injury - pathology
Acute respiratory distress syndrome
Animals
Bacterial pneumonia
Care and treatment
Chronic Disease
Complications and side effects
Diagnosis
Disease Models, Animal
Dosage and administration
Hydrochloric acid
Hydrochloric Acid - toxicity
Lung - drug effects
Lung - metabolism
Lung - pathology
Male
Pneumonia
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - pathology
Rabbits
Risk factors
Smoke inhalation injuries
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Summary:Hydrochloric acid is one of the most prevalent and hazardous chemicals. Accidental spills occur in industrial plants or during transportation. Exposure to HCl can induce severe health impairment, including acute and chronic pulmonary diseases. We have previously described the molecular, structural, and functional aspects of the development of chronic lung injury and pulmonary fibrosis caused by intratracheal instillation of HCl in mice. Although mouse models of human disease have many advantages, rodents are evolutionary far from human and exhibit significant anatomical and physiological differences. Genetic and anatomic similarities between rabbits and humans are significantly higher. Rabbit models of HCl-induced lung injury have been used sparsely to evaluate acute lung injury. In this study, for the first time, we utilized rabbits as a model of HCl-induced pulmonary fibrosis and chronic lung injury. We present molecular, histological, and functional evidence that demonstrate the utility of using this model for studying new pharmaceutics against pulmonary fibrosis.
ISSN:1465-993X
1465-9921
1465-993X
DOI:10.1186/s12931-024-03022-7