Assessment of reproductive function in male albino rat fed dietary meal supplemented with Mucuna pruriens seed powder

The occurrence of conflicting reports on the improvement of male reproductive function among humans fed diet containing the seed of Mucuna pruriens (MP) have raised a major concern in Nigeria. We assessed the effect of MP seed powder on the reproductive function in 32 adult male albino rats randomiz...

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Bibliographic Details
Published in:Heliyon 2019-10, Vol.5 (10), p.e02716-e02716, Article e02716
Main Authors: Ashidi, Joseph Senu, Owagboriaye, Folarin Ojo, Yaya, Funmilola Balikis, Payne, Deborah Eyinjuoluwa, Lawal, Olubukola Ireti, Owa, Stephen Olugbemiga
Format: Article
Language:English
Subjects:
Aphrodisiac
Biochemistry
Fertility
Mucuna pruriens
Oxidative stress
Plant biology
Reproductive hormones
Sperm quality
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Summary:The occurrence of conflicting reports on the improvement of male reproductive function among humans fed diet containing the seed of Mucuna pruriens (MP) have raised a major concern in Nigeria. We assessed the effect of MP seed powder on the reproductive function in 32 adult male albino rats randomized to 4 groups of 8 rats each for 8 weeks. Group 1 (control) was given standard rat chow while groups 2, 3 and 4 were fed diets containing MP seed powder at 0.75 g, 1.5 g and 2.25 g respectively. Serum level of follicle stimulating hormone, testosterone, luteinizing hormone, oxidative stress markers in the testis, epididymal sperm quality and cytoarchitectural structure of the testis were monitored using standard methods. Significant improvements (p < 0.05) in the serum levels of all the hormones, testicular antioxidant defence, epididymal sperm quality without testicular degenerative changes were observed in group 2 compared to other groups. Oxidative stress, severe degenerative architectural lesions in the testis as well as significant reductions (p < 0.05) in epididymal sperm count, percentage motility and significant (p < 0.05) increased in abnormal sperm cells were observed in group 4. MP seed enhances reproductive function in male rats only at a dose level of 0.75g. A dose value higher than 0.75 g may be toxic to the male reproductive system. Biochemistry; Plant biology; Aphrodisiac; Sperm quality; Mucuna pruriens; Reproductive hormones; Fertility; Oxidative stress
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2019.e02716