Corylus avellana L. modulates neurobehaviour and brain chemistry following high-fat diet

Consumption of a high-fat diet has adverse impacts on metabolism, neurobehavioral, and neurochemical homeostasis in both humans and experimental animals. Here, we examined the effects of two different cultivars of Corylus avellana L. in a mouse model of metabolic syndrome. Corylus avellana L. reduce...

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Bibliographic Details
Published in:Frontiers in bioscience (Landmark. Print) 2021-01, Vol.26 (3), p.537-551
Main Authors: Olofinnade, Anthony Tope, Onaolapo, Adejoke Yeunde, Onaolapo, Olakunle James, Olowe, Olugenga Adekunle, Mollica, Adriano, Zengin, Gokhan, Stefanucci, Azurra
Format: Article
Language:English
Subjects:
Animals
antioxidant
brain
corylus avellana
functional food
nutraceutical
neurobehaviour
metabolic
Behavior, Animal - drug effects
Brain Chemistry - drug effects
Corylus - chemistry
Diet, High-Fat
Feeding Behavior - drug effects
Humans
Male
Mice
Plant Extracts - pharmacology
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Summary:Consumption of a high-fat diet has adverse impacts on metabolism, neurobehavioral, and neurochemical homeostasis in both humans and experimental animals. Here, we examined the effects of two different cultivars of Corylus avellana L. in a mouse model of metabolic syndrome. Corylus avellana L. reduced weight gain in mice that were treated with a high-fat diet, improved their behavioral parameters as exemplified by locomotion and rearing, working-memory, and reduced grooming and anxiety indices. Both Corylus avellana L. varieties reduced blood glucose levels and lipid peroxidation, improved lipid profile, and antioxidant status in mice placed on a high fat diet. Finally, brain acetylcholinesterase activity was also reduced, dopamine level was increased, while caspase-3 level in the brain was reduced. Thus, the Corylus avellana L. cultivars improve metabolic, behavioral, and neurochemical homeostasis in a diet with a high-fat content.
ISSN:2768-6701
2768-6698
DOI:10.2741/4906