Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications

Mulberry ( spp.) is primarily used in sericulture, and its uses also extend to the food, pharmaceutical, and cosmetic industries. Mulberry extracts are rich in many bioactive compounds that exhibit a wide range of biological properties. Mulberroside F (Moracin M-6, 3'-di-O-β-D-glucopyranoside),...

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Bibliographic Details
Published in:Plants (Basel) 2022-12, Vol.12 (1), p.146
Main Authors: Thamrongwatwongsa, Jiralapat, Pattarapipatkul, Nattaya, Jaithon, Titiradsadakorn, Jindaruk, Ananya, Paemanee, Atchara, T-Thienprasert, Nattanan Panjaworayan, Phonphoem, Wannarat Pornsiriwong
Format: Article
Language:English
Subjects:
anti-tyrosinase
Bioactive compounds
Biocompatibility
Biological activity
Biological properties
Callus
Cell culture
Cell viability
Continuous production
Cosmeceuticals
Cosmetics
Cytotoxicity
Environmental aspects
Enzymes
Flavonoids
Food industry
Health aspects
Investigations
Medicinal plants
Melanin
Methods
Morus
Morus spp
mulberroside F
Mulberry
Pharmaceuticals
Phytochemicals
Plant tissue culture
Product development
Sericulture
Skin
Tissue culture
Toxicity
Tyrosinase
Ultraviolet radiation
Vero cells
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Summary:Mulberry ( spp.) is primarily used in sericulture, and its uses also extend to the food, pharmaceutical, and cosmetic industries. Mulberry extracts are rich in many bioactive compounds that exhibit a wide range of biological properties. Mulberroside F (Moracin M-6, 3'-di-O-β-D-glucopyranoside), one of the bioactive compounds found in mulberry, has previously been reported as a whitening agent by inhibiting melanin synthesis and exhibiting antioxidant effects. However, there is still limited information on the presence of this compound in plants cultured in vitro. In this study, the mulberroside F content, biochemical, and cytotoxic properties of the extracts from mulberry cultured in vitro were determined. The results revealed that both root and callus were found to be a potential source of mulberroside F. Furthermore, the mulberroside F content was positively correlated with the inhibitory effects on tyrosinase activity. Cell viability assay also revealed that crude extract of the mulberry root has no cytotoxicity in both human keratinocyte cell line (HaCaT) and Vero cells. Taken together, mulberry tissue culture represents a possible alternative and continuous production of mulberroside F, which could be further utilized in cosmeceutical applications.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants12010146