Betaine biosynthesis in a heterologous expression system based on the B12 producer Pseudomonas denitrificans

Glycine betaine is an important donor of methyl groups in various metabolic processes of the cell and acts as an osmoprotector when exposed to various abiotic stresses in pro- and eukaryotic organisms. Moreover, exogenous application of betaine activates the production of vitamin B12 in industrial s...

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Bibliographic Details
Main Authors: Shkryl, Yuri, Degtyarenko, Anton, Grigorchuk, Valeria, Balabanova, Larisa, Tekutyeva, Lyudmila
Format: Conference Proceeding
Language:English
Subjects:
Biosynthesis
Biotechnology
Fermentation
Glycine
Glycine betaine
Industrial strains
New technology
Pseudomonas
Vitamin B12
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Summary:Glycine betaine is an important donor of methyl groups in various metabolic processes of the cell and acts as an osmoprotector when exposed to various abiotic stresses in pro- and eukaryotic organisms. Moreover, exogenous application of betaine activates the production of vitamin B12 in industrial strains-producers. In this work, we have developed a new technology for microbiological betaine synthesis that can be used in biotechnology to activate B12 biosynthesis during large-scale fermentation of Pseudomonas denitrificans .
ISSN:2267-1242
2555-0403
2267-1242
DOI:10.1051/e3sconf/202022202047