The Effects of Working Memory Updating Training in Parkinson's Disease: A Feasibility and Single-Subject Study on Cognition, Movement and Functional Brain Response

In Parkinson's disease (PD), the fronto-striatal network is involved in motor and cognitive symptoms. Working memory (WM) updating training engages this network in healthy populations, as observed by improved cognitive performance and increased striatal BOLD signal. This two-part study aimed to...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in psychology 2021-01, Vol.11, p.587925-587925
Main Authors: Walton, Lois, Domellöf, Magdalena Eriksson, Boraxbekk, Carl-Johan, Domellöf, Erik, Rönnqvist, Louise, Bäckström, David, Forsgren, Lars, Stigsdotter Neely, Anna
Format: Article
Language:English
Subjects:
cognition
cognitive training
Engineering Psychology
functional magnetic resonance imaging
Medical Science
Medicinsk vetenskap
movement kinematics
neurologi
Neurology
Parkinson's disease
Psychology
Psychology with an emphasis on medical psychology
Psykologi inr. medicinsk psykologi
Teknisk psykologi
working memory
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In Parkinson's disease (PD), the fronto-striatal network is involved in motor and cognitive symptoms. Working memory (WM) updating training engages this network in healthy populations, as observed by improved cognitive performance and increased striatal BOLD signal. This two-part study aimed to assess the feasibility of WM updating training in PD and measure change in cognition, movement and functional brain response in one individual with PD after WM updating training. A feasibility and single-subject (FL) study were performed in which patients with PD completed computerized WM updating training. The outcome measures were the pre-post changes in criterion and transfer cognitive tests; cognitive complaints; psychological health; movement kinematics; and task-related BOLD signal. Participants in the feasibility study showed improvements on the criterion tests at post-test. FL displayed the largest improvements on the criterion tests and smaller improvements on transfer tests. Furthermore, FL reported improved cognitive performance in everyday life. A shorter onset latency and smoother upper-limb goal-directed movements were measured at post-test, as well as increased activation within the striatum and decreased activation throughout the fronto-parietal WM network. This two-part study demonstrated that WM updating training is feasible to complete for PD patients and that change occurred in FL at post-test in the domains of cognition, movement and functional brain response.
ISSN:1664-1078
1664-1078
DOI:10.3389/fpsyg.2020.587925