Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold

• Published in: Nano-micro letters 2019-10, Vol.11 (1), p.1-20, Article 93
• Main Authors: Chen, Jian-Li, Zhang, Han, Huang, Xue-Qin, Wan, Hong-Ye, Li, Jie, Fan, Xing-Xing, Luo, Kathy Qian, Wang, Jinhua, Zhu, Xiao-Ming, Wang, Jianfang
• Format: Article
• Language: English
• Subjects: Ablation; Antiangiogenesis therapy; Anticancer properties; Cancer; Conversion coating; Core@shell nanostructures; Electromagnetic absorption; Engineering; Gold coatings; Gold nanobipyramids; In vivo methods and tests; Infrared lasers; Infrared windows; Irradiation; Lasers; Nanobiomedicine; Nanoscale Science and Technology; Nanostructure; Nanotechnology; Nanotechnology and Microengineering; Near infrared radiation; Photothermal conversion; Photothermal therapy; Plasmon resonance; Synthesis; Therapy; Titanium dioxide
• ISSN: 2311-6706; 2150-5551
• DOI: 10.1007/s40820-019-0327-4

Highlights Titania-coated Au nanobipyramids (NBP@TiO 2 ) with a high photothermal conversion efficiency in the NIR-II window are synthesized. The TiO 2 shell is capable for the loading of the anticancer drug combretastatin A-4 phosphate (CA4P). The CA4P-loaded NBP@TiO 2 nanostructures subjected with photothermal therapy induce synergistic anticancer and antiangiogenesis effects under 1064-nm laser irradiation at a power density lower than the skin tolerance threshold value. Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region (1000–1350 nm) are strongly desired for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO 2 ) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO 2 nanostructures have a high photothermal conversion efficiency of (93.3 ± 5.2)% under 1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO 2 nanostructures combined with PTT induce a synergistic antiangiogenesis effect. In vivo studies show that such CA4P-loaded NBP@TiO 2 nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4 W cm −2 , which is lower than the skin tolerance threshold value, exhibit a superior antitumor effect. This work presents not only the development of the NBP@TiO 2 nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy.