Value analysis of preoperative peripheral blood LMR in predicting prognosis of serous papillary ovarian adenocarcinoma

• Published in: Discover. Oncology 2024-08, Vol.15 (1), p.377-11, Article 377
• Main Author: Qin, Lin
• Format: Article
• Language: English
• Subjects: Age; Biomarkers; Blood; Cancer Research; Chi-square test; Correlation analysis; Fatalities; Female reproductive system; Hospitals; Inflammation; Internal Medicine; Lymphocyte monocyte ratio (LMR); Mann-Whitney U test; Medical prognosis; Medicine; Medicine & Public Health; Molecular Medicine; Normal distribution; Oncology; Ovarian cancer; Prognosis; Radiotherapy; Serous papillary ovarian adenocarcinoma; Surgical Oncology; Tumors
• ISSN: 2730-6011; 2730-6011
• DOI: 10.1007/s12672-024-01264-x

Objective To analyze the predictive effect of preoperative peripheral blood leukocyte related inflammatory indicators on the prognosis of patients with serous papillary ovarian adenocarcinoma. Methods A retrospective analysis was conducted on the case data of 83 patients with ovarian cancer undergoing tumor cell reduction surgery admitted to our hospital from January 2017 to December 2020. Pathological findings confirmed serous papillary ovarian adenocarcinoma. Kaplan–Meier method was used to analyze the relationship between lymphocyte to monocyte ratio (LMR) and the patients survival prognosis. Analyzing factors affecting patient prognosis which using a multivariable Cox risk. Results The overall survival (OS) of the patients with serous papillary ovarian adenocarcinoma in high LMR group was higher than that in the low LMR group preoperative. The disease free survival (DFS) of ovarian adenocarcinoma patients in the high LMR group was higher than that in the low LMR group preoperative. That was the low LMR indicating a poor prognosis. Single factor analysis showed that age of onset was correlated with OS and DFS, and the body mass index (BMI) was only correlated with OS. Multivariable analysis showed that the age of onset (HR = 2.571, 95% CI 1.199–5.512, P = 0.015) and BMI (HR = 0.337, 95% CI 0.158–0.718, P = 0.005) were independent risk factors for OS. Conclusions Although the serous papillary ovarian adenocarcinoma patients with preoperative peripheral blood LMR reduction have poor prognosis, the correlation between LMR values and prognosis is not significant. Therefore, it is not recommended to use preoperative peripheral leukocyte related inflammatory indicators as prognostic markers for serous papillary ovarian adenocarcinoma.