Primary hepatic large B-cell lymphoma following direct-acting antiviral treatment for hepatitis C

Hepatitis C virus (HCV) infection is a major public health concern worldwide, raising important medical and economic issues. HCV-related end-stage liver disease is one of the most common indications for hepatic transplantation. Chronic hepatitis C is also assimilated to a systemic disease because of...

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Bibliographic Details
Published in:BMJ open gastroenterology 2021-08, Vol.8 (1), p.e000721
Main Authors: Zaimi, Yosra, Ayari, Myriam, Cherifi, Walid, Letaief Ksontini, Feryel, Ayadi, Shema, Bel Hadj Mabrouk, Emna, Jrad, Myriam
Format: Article
Language:English
Subjects:
Abdomen
Antigens
Antiviral drugs
Ascites
Biopsy
Blood tests
Bone marrow
Case reports
Endoscopy
Hemoglobin
Hepatitis
Hepatitis C
Hepatology
Hypertension
Interferon
Laboratories
Liver cancer
Liver cirrhosis
Liver diseases
Lymphatic diseases
Lymphoma
Medical history
Medical imaging
Patients
Proteins
Ultrasonic imaging
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Summary:Hepatitis C virus (HCV) infection is a major public health concern worldwide, raising important medical and economic issues. HCV-related end-stage liver disease is one of the most common indications for hepatic transplantation. Chronic hepatitis C is also assimilated to a systemic disease because of multiple extrahepatic manifestations, including lymphoproliferative disorders. The revolution of HCV treatment with the advent of direct-acting antivirals has significantly improved the management with high antiviral efficacy and good safety profile compared with old regimens, thus allowing good outcomes on hepatic and extrahepatic symptoms. However, with the widespread use of these new agents, controversial concerns about unexpected increasing cases of hepatocellular carcinoma were reported. We now report the case of a patient presenting with HCV-related cirrhosis, treated with direct-antiviral therapy and diagnosed with primary hepatic lymphoma shortly after the end of the treatment.
ISSN:2054-4774
2054-4774
DOI:10.1136/bmjgast-2021-000721