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Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are sight-threatening maculopathies with both environmental and genetic risk factors. We have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and PCV. In this s...
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| Published in: | Eye and vision (Novato, Calif.) Calif.), 2019-11, Vol.6 (1), p.34-34, Article 34 |
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| container_end_page | 34 |
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| container_title | Eye and vision (Novato, Calif.) |
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| creator | Liu, Ke Ma, Li Lai, Timothy Y Y Brelen, Marten E Tam, Pancy O S Tham, Clement C Pang, Chi Pui Chen, Li Jia |
| description | Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are sight-threatening maculopathies with both environmental and genetic risk factors. We have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and PCV.
In this study, we investigated the haplotype-tagging single nucleotide polymorphisms (SNPs) in the
(
) gene in 708 unrelated Chinese individuals: 200 neovascular AMD patients, 233 PCV patients and 275 controls. Six tagging SNPs in
were genotyped. Univariate single SNP association analysis, haplotype-based association analysis and gene-gene interaction analysis between
and other AMD-associated genes were performed.
The results revealed none of the six tagging SNPs of the
gene had a significant association with neovascular AMD or PCV (
> 0.05). We also found insignificant haplotype-based association, and no significant SNP-SNP interaction between
and other genes (including
-
-
-
,
,
,
,
,
,
and
) for neovascular AMD and PCV.
This study showed no statistical significance in the genetic association of
with neovascular AMD or PCV in a Hong Kong Chinese population. Further studies in large samples from different populations are warranted to elucidate the role of
in the genetic susceptibility of AMD and PCV. |
| doi_str_mv | 10.1186/s40662-019-0161-2 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_ae43ac95f7c441b3ae6fd2ca561955ea</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A605029271</galeid><doaj_id>oai_doaj_org_article_ae43ac95f7c441b3ae6fd2ca561955ea</doaj_id><sourcerecordid>A605029271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c563t-f3f15c41a86ea8337675152436018a90780997028b269a19565e2d887c6009123</originalsourceid><addsrcrecordid>eNptkl2L1DAUhoso7rLuD_BGCoJ40zUfTdrcCMuw6sKCN3odzqSnbZa0GZN2lsE_b2rXYQYkhJycvOchOXmz7C0lN5TW8lMsiZSsIFSlKWnBXmSXjDNZECbKlyfxRXYd4yMhhNK0q9jr7ILTihFO6GX2-24PbobJ-jH3bT71mEOM3thjaiPyJzv1-Yh-D9HMDkIOHRYBHUzY5AOsuQY7HDGsdTA2-c67w87bBlxueh_WaEX4HUz94U32qgUX8fp5vcp-frn7sflWPHz_er-5fSiMkHwqWt5SYUoKtUSoOa9kJahgJZeE1qBIVROlKsLqLZMKqBJSIGvqujKSEEUZv8ruV27j4VHvgh0gHLQHq_8mfOg0hMkahxqw5GCUaCtTlnTLAWXbMANCJq5ASKzPK2s3bwdsDI5TAHcGPT8Zba87v9ey5pKXKgE-PgOC_zVjnPRgo0HnIDV4jppxWjLBKiWS9P0q7SBdzY6tT0SzyPWtJIIwxSqaVDf_UaXR4GCNH7G1KX9W8OGkoEdwUx-9m5ePi-dCugpN8DEGbI_PpEQvHtSrB3XyoF48qJdevzvtz7Hin-P4H5yI1cs</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2314252795</pqid></control><display><type>article</type><title>Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Liu, Ke ; Ma, Li ; Lai, Timothy Y Y ; Brelen, Marten E ; Tam, Pancy O S ; Tham, Clement C ; Pang, Chi Pui ; Chen, Li Jia</creator><creatorcontrib>Liu, Ke ; Ma, Li ; Lai, Timothy Y Y ; Brelen, Marten E ; Tam, Pancy O S ; Tham, Clement C ; Pang, Chi Pui ; Chen, Li Jia</creatorcontrib><description>Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are sight-threatening maculopathies with both environmental and genetic risk factors. We have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and PCV.
In this study, we investigated the haplotype-tagging single nucleotide polymorphisms (SNPs) in the
(
) gene in 708 unrelated Chinese individuals: 200 neovascular AMD patients, 233 PCV patients and 275 controls. Six tagging SNPs in
were genotyped. Univariate single SNP association analysis, haplotype-based association analysis and gene-gene interaction analysis between
and other AMD-associated genes were performed.
The results revealed none of the six tagging SNPs of the
gene had a significant association with neovascular AMD or PCV (
> 0.05). We also found insignificant haplotype-based association, and no significant SNP-SNP interaction between
and other genes (including
-
-
-
,
,
,
,
,
,
and
) for neovascular AMD and PCV.
This study showed no statistical significance in the genetic association of
with neovascular AMD or PCV in a Hong Kong Chinese population. Further studies in large samples from different populations are warranted to elucidate the role of
in the genetic susceptibility of AMD and PCV.</description><identifier>ISSN: 2326-0254</identifier><identifier>EISSN: 2326-0254</identifier><identifier>DOI: 10.1186/s40662-019-0161-2</identifier><identifier>PMID: 31720301</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Age-related macular degeneration ; Complement (Immunology) ; Complete component 5 ; Genetic aspects ; Genetic association ; Health aspects ; Macular degeneration ; Microcirculation disorders ; Polypoidal choroidal vasculopathy ; Risk factors ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism</subject><ispartof>Eye and vision (Novato, Calif.), 2019-11, Vol.6 (1), p.34-34, Article 34</ispartof><rights>The Author(s). 2019.</rights><rights>COPYRIGHT 2019 BioMed Central Ltd.</rights><rights>The Author(s). 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-f3f15c41a86ea8337675152436018a90780997028b269a19565e2d887c6009123</citedby><cites>FETCH-LOGICAL-c563t-f3f15c41a86ea8337675152436018a90780997028b269a19565e2d887c6009123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836349/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836349/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31720301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Ke</creatorcontrib><creatorcontrib>Ma, Li</creatorcontrib><creatorcontrib>Lai, Timothy Y Y</creatorcontrib><creatorcontrib>Brelen, Marten E</creatorcontrib><creatorcontrib>Tam, Pancy O S</creatorcontrib><creatorcontrib>Tham, Clement C</creatorcontrib><creatorcontrib>Pang, Chi Pui</creatorcontrib><creatorcontrib>Chen, Li Jia</creatorcontrib><title>Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy</title><title>Eye and vision (Novato, Calif.)</title><addtitle>Eye Vis (Lond)</addtitle><description>Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are sight-threatening maculopathies with both environmental and genetic risk factors. We have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and PCV.
In this study, we investigated the haplotype-tagging single nucleotide polymorphisms (SNPs) in the
(
) gene in 708 unrelated Chinese individuals: 200 neovascular AMD patients, 233 PCV patients and 275 controls. Six tagging SNPs in
were genotyped. Univariate single SNP association analysis, haplotype-based association analysis and gene-gene interaction analysis between
and other AMD-associated genes were performed.
The results revealed none of the six tagging SNPs of the
gene had a significant association with neovascular AMD or PCV (
> 0.05). We also found insignificant haplotype-based association, and no significant SNP-SNP interaction between
and other genes (including
-
-
-
,
,
,
,
,
,
and
) for neovascular AMD and PCV.
This study showed no statistical significance in the genetic association of
with neovascular AMD or PCV in a Hong Kong Chinese population. Further studies in large samples from different populations are warranted to elucidate the role of
in the genetic susceptibility of AMD and PCV.</description><subject>Age-related macular degeneration</subject><subject>Complement (Immunology)</subject><subject>Complete component 5</subject><subject>Genetic aspects</subject><subject>Genetic association</subject><subject>Health aspects</subject><subject>Macular degeneration</subject><subject>Microcirculation disorders</subject><subject>Polypoidal choroidal vasculopathy</subject><subject>Risk factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><issn>2326-0254</issn><issn>2326-0254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkl2L1DAUhoso7rLuD_BGCoJ40zUfTdrcCMuw6sKCN3odzqSnbZa0GZN2lsE_b2rXYQYkhJycvOchOXmz7C0lN5TW8lMsiZSsIFSlKWnBXmSXjDNZECbKlyfxRXYd4yMhhNK0q9jr7ILTihFO6GX2-24PbobJ-jH3bT71mEOM3thjaiPyJzv1-Yh-D9HMDkIOHRYBHUzY5AOsuQY7HDGsdTA2-c67w87bBlxueh_WaEX4HUz94U32qgUX8fp5vcp-frn7sflWPHz_er-5fSiMkHwqWt5SYUoKtUSoOa9kJahgJZeE1qBIVROlKsLqLZMKqBJSIGvqujKSEEUZv8ruV27j4VHvgh0gHLQHq_8mfOg0hMkahxqw5GCUaCtTlnTLAWXbMANCJq5ASKzPK2s3bwdsDI5TAHcGPT8Zba87v9ey5pKXKgE-PgOC_zVjnPRgo0HnIDV4jppxWjLBKiWS9P0q7SBdzY6tT0SzyPWtJIIwxSqaVDf_UaXR4GCNH7G1KX9W8OGkoEdwUx-9m5ePi-dCugpN8DEGbI_PpEQvHtSrB3XyoF48qJdevzvtz7Hin-P4H5yI1cs</recordid><startdate>20191107</startdate><enddate>20191107</enddate><creator>Liu, Ke</creator><creator>Ma, Li</creator><creator>Lai, Timothy Y Y</creator><creator>Brelen, Marten E</creator><creator>Tam, Pancy O S</creator><creator>Tham, Clement C</creator><creator>Pang, Chi Pui</creator><creator>Chen, Li Jia</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20191107</creationdate><title>Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy</title><author>Liu, Ke ; Ma, Li ; Lai, Timothy Y Y ; Brelen, Marten E ; Tam, Pancy O S ; Tham, Clement C ; Pang, Chi Pui ; Chen, Li Jia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-f3f15c41a86ea8337675152436018a90780997028b269a19565e2d887c6009123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age-related macular degeneration</topic><topic>Complement (Immunology)</topic><topic>Complete component 5</topic><topic>Genetic aspects</topic><topic>Genetic association</topic><topic>Health aspects</topic><topic>Macular degeneration</topic><topic>Microcirculation disorders</topic><topic>Polypoidal choroidal vasculopathy</topic><topic>Risk factors</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ke</creatorcontrib><creatorcontrib>Ma, Li</creatorcontrib><creatorcontrib>Lai, Timothy Y Y</creatorcontrib><creatorcontrib>Brelen, Marten E</creatorcontrib><creatorcontrib>Tam, Pancy O S</creatorcontrib><creatorcontrib>Tham, Clement C</creatorcontrib><creatorcontrib>Pang, Chi Pui</creatorcontrib><creatorcontrib>Chen, Li Jia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Eye and vision (Novato, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ke</au><au>Ma, Li</au><au>Lai, Timothy Y Y</au><au>Brelen, Marten E</au><au>Tam, Pancy O S</au><au>Tham, Clement C</au><au>Pang, Chi Pui</au><au>Chen, Li Jia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy</atitle><jtitle>Eye and vision (Novato, Calif.)</jtitle><addtitle>Eye Vis (Lond)</addtitle><date>2019-11-07</date><risdate>2019</risdate><volume>6</volume><issue>1</issue><spage>34</spage><epage>34</epage><pages>34-34</pages><artnum>34</artnum><issn>2326-0254</issn><eissn>2326-0254</eissn><abstract>Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are sight-threatening maculopathies with both environmental and genetic risk factors. We have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and PCV.
In this study, we investigated the haplotype-tagging single nucleotide polymorphisms (SNPs) in the
(
) gene in 708 unrelated Chinese individuals: 200 neovascular AMD patients, 233 PCV patients and 275 controls. Six tagging SNPs in
were genotyped. Univariate single SNP association analysis, haplotype-based association analysis and gene-gene interaction analysis between
and other AMD-associated genes were performed.
The results revealed none of the six tagging SNPs of the
gene had a significant association with neovascular AMD or PCV (
> 0.05). We also found insignificant haplotype-based association, and no significant SNP-SNP interaction between
and other genes (including
-
-
-
,
,
,
,
,
,
and
) for neovascular AMD and PCV.
This study showed no statistical significance in the genetic association of
with neovascular AMD or PCV in a Hong Kong Chinese population. Further studies in large samples from different populations are warranted to elucidate the role of
in the genetic susceptibility of AMD and PCV.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>31720301</pmid><doi>10.1186/s40662-019-0161-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Eye and vision (Novato, Calif.), 2019-11, Vol.6 (1), p.34-34, Article 34 |
| issn | 2326-0254 2326-0254 |
| language | eng |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Age-related macular degeneration Complement (Immunology) Complete component 5 Genetic aspects Genetic association Health aspects Macular degeneration Microcirculation disorders Polypoidal choroidal vasculopathy Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism |
| title | Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy |
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