Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR: LA-cp rats

This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean contro...

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Bibliographic Details
Published in:Nutrients 2010-02, Vol.2 (2), p.181-197
Main Authors: Ruth, Megan R, Wang, Ye, Yu, Howe-Ming, Goruk, Susan, Reaney, Martin J, Proctor, Spencer D, Vine, Donna F, Field, Catherine J
Format: Article
Language:English
Subjects:
Animals
Case-Control Studies
Cytokines
Cytokines - biosynthesis
Diabetes
Diet
Disease Models, Animal
elaidic acid
Fatty acids
Fatty Acids - metabolism
Haptoglobins - metabolism
Hydrogenation
immune
Inflammation
Insulin
Insulin Resistance
Metabolic disorders
Mitogens - pharmacology
obese
Obesity
Obesity - metabolism
Oleic Acid - administration & dosage
Oleic Acid - pharmacology
Oleic Acids - administration & dosage
Oleic Acids - pharmacology
Overweight
phospholipid
Phospholipids - chemistry
Phospholipids - metabolism
Plasma
Rats
Rodents
Spleen - metabolism
trans fat
vaccenic acid
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Summary:This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean control (Ctl), obese Ctl rats had higher serum haptoglobin and impaired T-cell-stimulated cytokine responses. VA and EA diets improved T-cell-stimulated cytokine production; but, only VA normalized serum haptoglobin. However, EA- and VA-fed rats had enhanced LPS-stimulated cytokine responses. The changes elicited by VA were likely due changes in essential fatty acid composition in PL; whereas EA-induced changes may due to direct incorporation into membrane PL.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu2020181