Feasibility of dual‐task gait to estimate Alzheimer's related cognitive decline in Down syndrome

Introduction The striatum and frontal lobes have been shown to have early Alzheimer's disease (AD) neuropathology and are critical for motor and cognitive function. We hypothesized gait would be associated with early‐stage dementia in Down syndrome (DS), a cohort at risk for AD. Methods Twenty‐...

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Bibliographic Details
Published in:Alzheimer's & dementia : diagnosis, assessment & disease monitoring assessment & disease monitoring, 2020, Vol.12 (1), p.e12092-n/a
Main Authors: Van Pelt, Kathryn L., Koehl, Lisa, Caban‐Holt, Allison, Anderson‐Mooney, Amelia, Head, Elizabeth, Schmitt, Frederick A.
Format: Article
Language:English
Subjects:
Age
aging
Alzheimer's disease
Brain research
Caregivers
Cognition & reasoning
Cognitive ability
Dementia
Down syndrome
dual‐task effect
gait speed
Guardians
Intellectual disabilities
Neuropathology
Population
trisomy21
Velocity
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Summary:Introduction The striatum and frontal lobes have been shown to have early Alzheimer's disease (AD) neuropathology and are critical for motor and cognitive function. We hypothesized gait would be associated with early‐stage dementia in Down syndrome (DS), a cohort at risk for AD. Methods Twenty‐eight participants with DS were enrolled in the study. Participants walked at their self‐selected pace and while completing a dual task (counting, obstacle, or counting+obstacle). Results All participants were able to complete the self‐paced condition and 78.57–96.42% completed the dual‐task conditions. There was a trend for greater dual‐task effects on gait velocity based on dementia diagnosis. Gait velocity had stronger associations with clinical dementia assessments than age or diagnosis. Discussion A dual‐task gait paradigm is feasible to conduct with adults with DS and is associated with age and cognitive impairment. Dual‐task gait may serve as an indicator of early stage dementia in DS.
ISSN:2352-8729
2352-8729
DOI:10.1002/dad2.12092