Facile Preparation of Co3O4 Hollow Dodecahedron with Superior Peroxidase-like Activity for Selective Detection of Cholesterol

The Co3O4 hollow dodecahedron (Co3O4@CN) was prepared by calcining ZIF-67 in N2 and then air atmosphere. In the Co3O4@CN compound material, Co3O4 nanoparticles (Co3O4 NPs) are anchored in the carbon skeleton, solving the aggregation problem of Co3O4 NPs. Because Co3O4@CN retains the porous structure...

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Bibliographic Details
Published in:Chemosensors 2023-01, Vol.11 (1), p.27
Main Authors: Liu, Meili, Xue, Liuheng, Feng, Qinghua, Wang, Yingsha, Liu, Jia, Zhang, Shouting, Hu, Wenping
Format: Article
Language:English
Subjects:
Carbon
Carbon dioxide
Cardiovascular disease
Chemical industry
Cholesterol
cholesterol sensor
Co3O4@CN compound material
Cobalt
Cobalt oxides
Electron transfer
Enzymes
High temperature
Metal oxides
Methods
Nanocomposites
Nanomaterials
Nanoparticles
Nitrates
Peroxidase
peroxidase-like activity
Sensors
Substrates
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Summary:The Co3O4 hollow dodecahedron (Co3O4@CN) was prepared by calcining ZIF-67 in N2 and then air atmosphere. In the Co3O4@CN compound material, Co3O4 nanoparticles (Co3O4 NPs) are anchored in the carbon skeleton, solving the aggregation problem of Co3O4 NPs. Because Co3O4@CN retains the porous structure of ZIF-67, and the presence of Co2+ and Co3+ favors electron transfer between the enzyme substrates, it has excellent peroxidase-like (POD-like) activity. Enzymatic kinetic tests show that Co3O4@CN has approximately six times more affinity for TMB than HRP and the maximal reaction rate is approximately three times that of HRP. The cholesterol sensor was constructed with Co3O4@CN, and its linear range was 20-1000 μM, and the detection limit was 14.33 μM. The application of Co3O4@CN to the detection of human serum cholesterol will be a valuable research direction.
ISSN:2227-9040
2227-9040
DOI:10.3390/chemosensors11010027