Susceptibility of Genetic Variations in Methylation Pathway to Gastric Cancer

DNA methylation in the CpG island is associated with gastric cancer, genetic variations residue in genes involved in methylation pathway could contribute to the occurrence of gastric cancer. Here, we investigated the association between ( ), genetic variations and gastric cancer risk and patients�...

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Bibliographic Details
Published in:Pharmacogenomics and personalized medicine 2022, Vol.15, p.441-448
Main Authors: Xiong, Mengqiu, Pan, Bei, Wang, Xuhong, Nie, Junjie, Pan, Yuqin, Sun, Huiling, Xu, Tao, Cho, William C S, Wang, Shukui, He, Bangshun
Format: Article
Language:English
Subjects:
Analysis
Disease susceptibility
dnmts
gastric cancer
Genes
Genetic aspects
genetic variation
Health aspects
Helicobacter infections
Methylation
Methyltransferases
mthfr
Original Research
Stomach cancer
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Summary:DNA methylation in the CpG island is associated with gastric cancer, genetic variations residue in genes involved in methylation pathway could contribute to the occurrence of gastric cancer. Here, we investigated the association between ( ), genetic variations and gastric cancer risk and patients' survival. We recruited 490 gastric cancer patients and 488 age- and sex-matched healthy controls. The genotypes of the genetic variations were detected by a Mass-array platform. A commercial ( ) immunogold testing kit was used to determine the infection. We found that carriers of rs2228612C allele was associated with decreased gastric cancer risk (CT vs. TT: adjusted OR = 0.70, 95% CI = 0.53-0.94, = 0.02; CT/CC vs.TT: adjusted OR = 0.73, 95% CI = 0.56-0.96, = 0.02). Further stratified analysis showed that rs2228612 CT/CC were associated with a decreased gastric cancer risk in the subgroups of age ≤64 years old (adjusted OR = 0.61, 95% CI = 0.41-0.90, = 0.01), male (adjusted OR = 0.72, 95% CI = 0.53-0.98, = 0.03), negative infection (adjusted OR = 0.67, 95% CI = 0.45-0.98, = 0.04), tumor stage T3-T4 (adjusted OR = 0.69, 95% CI = 0.51-0.92, = 0.01), and non-gastric cardiac adenocarcinoma (NGCA) (adjusted OR = 0.72, 95% CI = 0.54-0.97, = 0.03). However, none of the genetic variations of this study was associated with overall survival. We concluded that the rs2228612C genotype is a protective factor for gastric cancer in Han Chinese population.
ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S340941