The performance of a combination of heparin-binding protein with other biomarkers for sepsis diagnosis: an observational cohort study

• Published in: BMC infectious diseases 2024-07, Vol.24 (1), p.755-11, Article 755
• Main Authors: Feng, Liwei, Liu, Shujie, Wang, Jieying, Gao, Yan, Xie, Fengjie, Gong, Jianguo, Bi, Sheng, Yao, Zhipeng, Li, Yue, Liu, Wenhua, Guan, Chunming, Zhang, Ming, Wang, Hongliang, Zheng, Junbo
• Format: Article
• Language: English
• Subjects: Adult; Aged; Albumin; Analysis; Anticoagulants; Antimicrobial Cationic Peptides - blood; Biological markers; Biomarkers; Biomarkers - blood; Blood; Blood Proteins - analysis; CAP37 protein; Care and treatment; Chemokines; China; Cohort analysis; Cohort Studies; Complications and side effects; Cytokines; Diagnosis; Diagnostic systems; Dosage and administration; Ethylenediaminetetraacetic acid; Female; Health aspects; Hematology; Heparin; Heparin-binding protein; Humans; Infection; Infections; Inflammation; Interleukin 6; Interleukin 8; Interleukin-6 - blood; Interleukin-8 - blood; Laboratories; Leukocytes (neutrophilic); Male; Medical research; Medicine, Experimental; Middle Aged; Mortality; Normal distribution; Observational studies; Patients; Performance indices; Permeability; Protein binding; Proteins; Regression analysis; Sepsis; Sepsis - blood; Sepsis - diagnosis; Septic shock; Shock, Septic - blood; Shock, Septic - diagnosis; Statistical analysis; Ventilators
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-024-09666-6

HBP, a novel biomarker released from neutrophils, may induce inflammatory responses and exacerbate vascular permeability, representing the pathophysiological characteristics of sepsis and septic shock. However, it remains uncertain whether the combination of HBP with other biomarkers yields enhanced diagnostic capacity for sepsis. We hypothesized that measurements included IL-6·IL-8·HBP, IL-6·IL-8·HBP/ALB and HBP/ALB which based on HBP will improve its diagnostic efficacy and even better than the traditional infection biomarkers. Between July 2021 and June 2022, we carried out a comprehensive, multi-center, observational cohort study spanning six leading tertiary hospitals located in Heilongjiang Province, China. Patients were stratified into three categories based on the severity of infection: non-sepsis, sepsis, and septic shock. We collected clinical and laboratory data, along with infection and inflammation biomarkers, for analysis. A total of 195 patients were enrolled. Among the three groups, patients with septic shock (n = 75, 38.5%) had significantly higher baseline levels of HBP, WBC, Lac, CRP, PCT, IL-6, IL-8, and IL-10 compared to non-sepsis patients (n = 43, 22.0%) and sepsis patients (n = 77, 39.5%), with statistically significant differences (p