The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial

Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS). We hypothesized that magnesium supplementation would yield beneficial effects on PCOS related complications. To examine the effects of magnesium supplementati...

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Bibliographic Details
Published in:Reproductive biology and endocrinology 2022-08, Vol.20 (1), p.110-11, Article 110
Main Authors: Jaripur, Mahsima, Ghasemi-Tehrani, Hatav, Askari, Gholamreza, Gholizadeh-Moghaddam, Mahsa, Clark, Cain C T, Rouhani, Mohammad Hossein
Format: Article
Language:English
Subjects:
Abnormal uterine bleeding
Acne
Acne Vulgaris - complications
Acne Vulgaris - drug therapy
Alopecia
Alopecia - complications
Alopecia - drug therapy
Androgens
Baldness
Biomarkers
Bleeding
Clinical trials
Diabetes
Dietary Supplements
Emotions
Female
Gynecology
Hair loss
Hospitals
Humans
Infertility
Magnesium
Magnesium - pharmacology
Magnesium - therapeutic use
Menstruation
Obstetrics
Ovaries
Placebos
Polycystic ovary syndrome
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - drug therapy
Pregnancy
Quality of Life
Stein-Leventhal syndrome
Supplements
Surveys
Ultrasonic imaging
Uterine bleeding
Uterine Hemorrhage - complications
Uterus
Womens health
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Summary:Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS). We hypothesized that magnesium supplementation would yield beneficial effects on PCOS related complications. To examine the effects of magnesium supplementation on AUB, alopecia, quality of life, and acne. In this parallel randomized clinical trial, we randomly assigned 64 women with PCOS to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. AUB, alopecia, quality of life, and acne were assessed by the International Federation of Gynecology and Obstetrics criterion, the Sinclair Scale, the Health Survey Quality of Life Questionnaire, and the Global Acne Grading System, respectively. This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N9). Magnesium supplementation significantly improved the components of quality of life including physical functioning (p = 0.011), role limitations due to physical health (p = 0.012), role limitations due to emotional problems (p 
ISSN:1477-7827
1477-7827
DOI:10.1186/s12958-022-00982-7