RelB and Neuroinflammation

Neuroinflammation within the central nervous system involves multiple cell types that coordinate their responses by secreting and responding to a plethora of inflammatory mediators. These factors activate multiple signaling cascades to orchestrate initial inflammatory response and subsequent resolut...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-06, Vol.10 (7), p.1609
Main Authors: Mockenhaupt, Karli, Gonsiewski, Alexandra, Kordula, Tomasz
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
astrocytes
Binding sites
Brain - pathology
Cell activation
Central nervous system
Chemokines
Cytokines
Dendritic cells
Gene expression
Humans
Immune system
Immunosuppression Therapy
Inflammation
Inflammation - pathology
Kinases
Ligands
microglia
Neurodegeneration
neuroinflammation
NF-kappa B - metabolism
NF-κB
NF-κB protein
oligodendrocytes
Phosphorylation
RelB
RelB protein
Review
Signal Transduction
Transcription Factor RelB - metabolism
Transcription factors
Tumor necrosis factor-TNF
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Summary:Neuroinflammation within the central nervous system involves multiple cell types that coordinate their responses by secreting and responding to a plethora of inflammatory mediators. These factors activate multiple signaling cascades to orchestrate initial inflammatory response and subsequent resolution. Activation of NF-κB pathways in several cell types is critical during neuroinflammation. In contrast to the well-studied role of p65 NF-κB during neuroinflammation, the mechanisms of RelB activation in specific cell types and its roles during neuroinflammatory response are less understood. In this review, we summarize the mechanisms of RelB activation in specific cell types of the CNS and the specialized effects this transcription factor exerts during neuroinflammation.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10071609