Evaluation of Protective and Therapeutics Effects of Baicalein in Rat Kidney Stone Models Induced by Ethylene Glycol and Hydroxy-L-Proline

Objective: To explore the effect of baicalein on the development and treatment of renal stones in a rat model induced by ethylene glycol or hydroxyproline. Materials and Methods: A grand total of 63 rats were split into nine distinct groups, each comprising seven rats: control, baicalein, ethylene g...

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Published in:Journal of urological surgery 2024-12, Vol.11 (4), p.201-207
Main Authors: Yoldas, Emre, Tanrikut, Cihan, Ustuner, Mehmet Cengiz, Ozkidik, Mete, Baseskioglu, Barbaros, Yenilmez, Aydin
Format: Article
Language:English
Subjects:
baicalein
Bioflavonoids
Drug therapy
Ethylene glycol
Flavones
Flavonoids
Health aspects
Hydroxyproline
Kidney stones
phytochemicals
rat kidney
Testing
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Summary:Objective: To explore the effect of baicalein on the development and treatment of renal stones in a rat model induced by ethylene glycol or hydroxyproline. Materials and Methods: A grand total of 63 rats were split into nine distinct groups, each comprising seven rats: control, baicalein, ethylene glycol (EG), baicalein+ethylene glycol (BE), ethylene glycol+baicalein (EB), dimethyl sulfoxide (DMSO), hydroxy-L-proline (HP), baicalein+hydroxyproline (BH), and hydroxyproline+baicalein (HB) respectively. Urinary stone formation was induced in rats using EG or HP. Rat kidneys were examined by two histologists using light and electron microscopes. Calcium oxalate crystals and cellular changes were examined. Kidney injury molecule-1 (KIM-1), N-acetyl-[beta]-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin and interleukin-18 (IL-18) levels were measured as potential biomarkers in both the kidney tissue and blood. Results: There was no noticeable difference in histological features when the specimens were examined under a light microscope. Kidney stone formation and mitochondrial differences were observed in the EG and HP groups in electron microscopic (EM) examinations; however, EM findings were normal in all preventive and therapeutic groups. Serum IL-18 and KIM-1 levels were significantly lower in the therapeutic group than in the EG and HP groups (p
ISSN:2148-9580
2148-9580
DOI:10.4274/jus.galenos.2024.2024-3-4