A Novel Metabolic Score for Predicting the Acute Exacerbation in Patients with Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) has higher mortality when developing to acute exacerbation (AECOPD); hence, the early intervention of COPD is critical for preventing AECOPD. Exploring the serum metabolites associated with acute exacerbation in patients with COPD will contribute to the e...

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Published in:International journal of chronic obstructive pulmonary disease 2023-01, Vol.18, p.785-795
Main Authors: Peng, Ling, You, Hong, Xu, Mei-Yu, Dong, Zhou-Yu, Liu, Min, Jin, Wen-Jing, Zhou, Chao
Format: Article
Language:English
Subjects:
acute exacerbation
aecopd
Analysis
China
copd
Development and progression
Disease Progression
Glutamate
Glutamine
Health aspects
Humans
Isoleucine
Lung diseases, Obstructive
Medical research
Medicine, Experimental
Metabolites
metabolomics
Mortality
Original Research
Prognosis
Pulmonary Disease, Chronic Obstructive - epidemiology
Pyruvates
Unsaturated fatty acids
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Summary:Chronic obstructive pulmonary disease (COPD) has higher mortality when developing to acute exacerbation (AECOPD); hence, the early intervention of COPD is critical for preventing AECOPD. Exploring the serum metabolites associated with acute exacerbation in patients with COPD will contribute to the early intervention of COPD. In the study, a non-targeted metabolomics strategy combined with multivariate statistical methods was performed to explore the metabolic profiling of COPD developing acute exacerbation, to screen the potential metabolites associated with AECOPD and to analyze the potential value of these metabolites in predicting the development of COPD. Serum lysine, glutamine, 3-hydroxybutyrate, pyruvate and glutamate levels were significantly higher, while 1-methylhistidine, isoleucine, choline, valine, alanine, histidine and leucine levels were significantly lower in AECOPD patients, compared with stable COPD patients after normalization based on the healthy controls. Moreover, eight metabolic pathways were significantly altered (P
ISSN:1178-2005
1176-9106
1178-2005
DOI:10.2147/COPD.S405547