Development of a prognostic nomogram for patients with malignant mesothelioma with bone metastasis

Malignant mesothelioma (MM) is a rare aggressive tumor, and bone metastasis often occurs in later stages of this disease. This study aimed to establish a nomogram to predict the prognosis of bone metastasis of patients with MM. Data from the Surveillance, Epidemiology, and End Results database were...

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Bibliographic Details
Published in:Scientific reports 2023-07, Vol.13 (1), p.10789-9, Article 10789
Main Authors: Yang, Awen, Tang, Bin, Liu, Xuan, He, Jingxuan, Yan, Qun, Liang, Xianghui, Liu, Wenen
Format: Article
Language:English
Subjects:
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Bone Neoplasms
Chemotherapy
Epidemiology
Humanities and Social Sciences
Humans
Medical prognosis
Mesothelioma
Mesothelioma, Malignant
Metastases
Metastasis
multidisciplinary
Nomograms
Prognosis
Radiation therapy
Risk factors
Science
Science (multidisciplinary)
SEER Program
Statistical analysis
Survival
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Summary:Malignant mesothelioma (MM) is a rare aggressive tumor, and bone metastasis often occurs in later stages of this disease. This study aimed to establish a nomogram to predict the prognosis of bone metastasis of patients with MM. Data from the Surveillance, Epidemiology, and End Results database were screened and retrieved. This study included 311 patients with MM with bone metastases. Prognostic factors were analyzed using the Kaplan–Meier method and Cox proportional hazards model. A nomogram for overall survival (OS) was established and evaluated using statistically significant prognostic factors, and cancer-specific survival (CSS) analysis was performed to investigate its prognostic factors. In addition, the metastasis patterns of patients with MM were investigated, and the effects of different sites of metastasis on survival were compared using the Kaplan–Meier method. Age, sex, histological type, and chemotherapy were identified as the independent risk factors for OS. The 1-, 2-, and 3-year areas under the curve of the nomogram were 0.792, 0.774, and 0.928, and 0.742, 0.733, and 0.733 in the training and validation sets, respectively. Compared to OS, histological type, radiotherapy, and chemotherapy were independent risk factors for CSS. Different metastatic sites in MM have significantly different effects on prognosis.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-37679-9