Genome and proteome screening of Onchocerca volvulus reveal putative vaccine candidates

Recent studies depict transmembrane proteins potential targets for chimeric multi-epitope vaccine; stimulate cellular and humoral immune responses by inducing B-cells and IFN-γ based immunity [2]. Uncharacterized protein sequences in Onchocerca volvulus sharing orthologues with Dirofilaria immitis a...

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Bibliographic Details
Published in:Molecular biomedicine 2021-12, Vol.2 (1), p.39-39, Article 39
Main Authors: Sheyin, Abraham, Gbem, Thaddeus Terlumun, Gaiya, Daniel Danladi, Nok, Jonathan Andrew
Format: Article
Language:English
Subjects:
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Chitinase
Genomes
Letter
Molecular Medicine
Pathogens
Peptides
Proteins
Tropical diseases
Vaccines
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Summary:Recent studies depict transmembrane proteins potential targets for chimeric multi-epitope vaccine; stimulate cellular and humoral immune responses by inducing B-cells and IFN-γ based immunity [2]. Uncharacterized protein sequences in Onchocerca volvulus sharing orthologues with Dirofilaria immitis and/or Brugia malayi and suggested putative functions O. volvulus protein Predicted function/description D. immitis orthologues B. malayi Orthologues Single TMH Secretory signal peptide B-cell Epitopes T-cell epitopes A0A044RMM8 Impervious cuticlin protein AF453385.1 XM 001898524.1 + + GVEGEPEIE, RNDEG, GGPTGQ, NG, SE, CSEP, GAATR PTDLMAGQEAHVY A0A044R5Q7 Impervious cuticlin protein – XM 001902142.1 + + DSPNG, QD, NIP, EFQTSPTTSTS, PDV, SGE, SPKTSET, STR, TV STDDFILPQLTY A0A044QSB0 Impervious cuticlin protein – XM 001895330.1 + + GVEGDPEI, CRSDEG, GPTGEPV, NG, GECARPECPEPQ, QPVQQPVE, DDNH PTDLMAGQEAHVY A0A044R521 Impervious cuticlin protein – XM 001902757.1 + + GVEGEPEIE, CRSDSG, GPTGT, DGKG, CPRPQCPE, PQ, AQ LSDLMAGQEAHVY A0A044VHR0 Zona pellucida-like domain containing protein – XM 001900794.1 + + FTP, QSM, RK, RR VIDENGCTLDSY, LSSKHADFNANHEY, NSDATMHDY A0A044RMF0 Hypothetical protein – XM 001896012.1 + + * VSSDFSLFLY, VMDDVSSDFSLFLY, SSDFSLFLY A0A044SEB3 Hypothetical protein – XM 001897289.1 + + TT, ESGK, VK, NR, ETS SSSPAASTVIEMLY, A0A044TJF8 Hypothetical protein – XM 001899259.1 + + NGA, IRPPP, SDSPSESAH, PRT, EKA CTSWVQPQIGIY, TLDIRMTKTDRY, KTDRYDYLLQFCTY Only tblastn results with E -value of 0.0 or E 
ISSN:2662-8651
2662-8651
DOI:10.1186/s43556-021-00062-z