Genome and proteome screening of Onchocerca volvulus reveal putative vaccine candidates

Recent studies depict transmembrane proteins potential targets for chimeric multi-epitope vaccine; stimulate cellular and humoral immune responses by inducing B-cells and IFN-γ based immunity [2]. Uncharacterized protein sequences in Onchocerca volvulus sharing orthologues with Dirofilaria immitis a...

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Published in:Molecular biomedicine 2021-12, Vol.2 (1), p.39-39, Article 39
Main Authors: Sheyin, Abraham, Gbem, Thaddeus Terlumun, Gaiya, Daniel Danladi, Nok, Jonathan Andrew
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Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Chitinase
Genomes
Letter
Molecular Medicine
Pathogens
Peptides
Proteins
Tropical diseases
Vaccines
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description Recent studies depict transmembrane proteins potential targets for chimeric multi-epitope vaccine; stimulate cellular and humoral immune responses by inducing B-cells and IFN-γ based immunity [2]. Uncharacterized protein sequences in Onchocerca volvulus sharing orthologues with Dirofilaria immitis and/or Brugia malayi and suggested putative functions O. volvulus protein Predicted function/description D. immitis orthologues B. malayi Orthologues Single TMH Secretory signal peptide B-cell Epitopes T-cell epitopes A0A044RMM8 Impervious cuticlin protein AF453385.1 XM 001898524.1 + + GVEGEPEIE, RNDEG, GGPTGQ, NG, SE, CSEP, GAATR PTDLMAGQEAHVY A0A044R5Q7 Impervious cuticlin protein – XM 001902142.1 + + DSPNG, QD, NIP, EFQTSPTTSTS, PDV, SGE, SPKTSET, STR, TV STDDFILPQLTY A0A044QSB0 Impervious cuticlin protein – XM 001895330.1 + + GVEGDPEI, CRSDEG, GPTGEPV, NG, GECARPECPEPQ, QPVQQPVE, DDNH PTDLMAGQEAHVY A0A044R521 Impervious cuticlin protein – XM 001902757.1 + + GVEGEPEIE, CRSDSG, GPTGT, DGKG, CPRPQCPE, PQ, AQ LSDLMAGQEAHVY A0A044VHR0 Zona pellucida-like domain containing protein – XM 001900794.1 + + FTP, QSM, RK, RR VIDENGCTLDSY, LSSKHADFNANHEY, NSDATMHDY A0A044RMF0 Hypothetical protein – XM 001896012.1 + + * VSSDFSLFLY, VMDDVSSDFSLFLY, SSDFSLFLY A0A044SEB3 Hypothetical protein – XM 001897289.1 + + TT, ESGK, VK, NR, ETS SSSPAASTVIEMLY, A0A044TJF8 Hypothetical protein – XM 001899259.1 + + NGA, IRPPP, SDSPSESAH, PRT, EKA CTSWVQPQIGIY, TLDIRMTKTDRY, KTDRYDYLLQFCTY Only tblastn results with E -value of 0.0 or E 
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Uncharacterized protein sequences in Onchocerca volvulus sharing orthologues with Dirofilaria immitis and/or Brugia malayi and suggested putative functions O. volvulus protein Predicted function/description D. immitis orthologues B. malayi Orthologues Single TMH Secretory signal peptide B-cell Epitopes T-cell epitopes A0A044RMM8 Impervious cuticlin protein AF453385.1 XM 001898524.1 + + GVEGEPEIE, RNDEG, GGPTGQ, NG, SE, CSEP, GAATR PTDLMAGQEAHVY A0A044R5Q7 Impervious cuticlin protein – XM 001902142.1 + + DSPNG, QD, NIP, EFQTSPTTSTS, PDV, SGE, SPKTSET, STR, TV STDDFILPQLTY A0A044QSB0 Impervious cuticlin protein – XM 001895330.1 + + GVEGDPEI, CRSDEG, GPTGEPV, NG, GECARPECPEPQ, QPVQQPVE, DDNH PTDLMAGQEAHVY A0A044R521 Impervious cuticlin protein – XM 001902757.1 + + GVEGEPEIE, CRSDSG, GPTGT, DGKG, CPRPQCPE, PQ, AQ LSDLMAGQEAHVY A0A044VHR0 Zona pellucida-like domain containing protein – XM 001900794.1 + + FTP, QSM, RK, RR VIDENGCTLDSY, LSSKHADFNANHEY, NSDATMHDY A0A044RMF0 Hypothetical protein – XM 001896012.1 + + * VSSDFSLFLY, VMDDVSSDFSLFLY, SSDFSLFLY A0A044SEB3 Hypothetical protein – XM 001897289.1 + + TT, ESGK, VK, NR, ETS SSSPAASTVIEMLY, A0A044TJF8 Hypothetical protein – XM 001899259.1 + + NGA, IRPPP, SDSPSESAH, PRT, EKA CTSWVQPQIGIY, TLDIRMTKTDRY, KTDRYDYLLQFCTY Only tblastn results with E -value of 0.0 or E &lt; 1e-50 was considered. ‘+’ = single transmembrane helice and secretory signal peptide present. There was a consensus for common predictions among the four programs; SignalP, TargetP, TMHMM and Phobius for only 22 protein sequences (Supplementary Table 1) and immunogenic epitopes that can trigger humoral and cell-mediated immunity was predicted from these 22 sequences (Table 1 and Supplementary Table 2). AbbreviationsHLA-A Human Leukocyte AntigenNCBI National Center for Biotechnology InformationMHC Major Histocompatibility ComplexTMHs Transmembrane HelicesTMH Transmembrane HelixTMHMM Tied Mixture Hidden Markov Model Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</description><identifier>ISSN: 2662-8651</identifier><identifier>EISSN: 2662-8651</identifier><identifier>DOI: 10.1186/s43556-021-00062-z</identifier><identifier>PMID: 34907469</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Bioinformatics ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biotechnology ; Chitinase ; Genomes ; Letter ; Molecular Medicine ; Pathogens ; Peptides ; Proteins ; Tropical diseases ; Vaccines</subject><ispartof>Molecular biomedicine, 2021-12, Vol.2 (1), p.39-39, Article 39</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. 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There was a consensus for common predictions among the four programs; SignalP, TargetP, TMHMM and Phobius for only 22 protein sequences (Supplementary Table 1) and immunogenic epitopes that can trigger humoral and cell-mediated immunity was predicted from these 22 sequences (Table 1 and Supplementary Table 2). AbbreviationsHLA-A Human Leukocyte AntigenNCBI National Center for Biotechnology InformationMHC Major Histocompatibility ComplexTMHs Transmembrane HelicesTMH Transmembrane HelixTMHMM Tied Mixture Hidden Markov Model Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34907469</pmid><doi>10.1186/s43556-021-00062-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6905-2103</orcidid><oa>free_for_read</oa></addata></record>
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subjects Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Chitinase
Genomes
Letter
Molecular Medicine
Pathogens
Peptides
Proteins
Tropical diseases
Vaccines
title Genome and proteome screening of Onchocerca volvulus reveal putative vaccine candidates
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