Vaccinations and Autoimmune Diseases

• Published in: Vaccines (Basel) 2021-07, Vol.9 (8), p.815
• Main Authors: Olivieri, Bianca, Betterle, Corrado, Zanoni, Giovanna
• Format: Article
• Language: English
• Subjects: Adverse events; Antigens; Arthritis; Autoimmune diseases; autoimmunity; Chicken pox; Disabilities; Disease; Encephalitis; Epidemiology; Guillain-Barre syndrome; Guillain-Barré syndrome; Hypotheses; Immune system; Immunization; Infections; Measles; Meningitis; Mortality; Mumps; Myocarditis; Pandemics; Pathogenesis; Pneumonia; Public health; Purpura; Review; Rubella; SARS-CoV2 vaccines; Severe acute respiratory syndrome coronavirus 2; Side effects; Surveillance; Thrombocytopenia; Vaccines; Viruses
• ISSN: 2076-393X; 2076-393X
• DOI: 10.3390/vaccines9080815

Vaccines represent one of the most effective measures of public health medicine, saving countless lives and preventing lifelong disabilities. Vaccines are extremely safe, however, no vaccine is completely free from risks and adverse events can occur following vaccination. An adverse event following immunization (AEFI) may be a true adverse reaction caused by the vaccine or an event that temporally occurred after immunization but is not caused by it. Among the adverse reactions to vaccines, one of the most feared is the triggering of autoimmune diseases, which are a heterogeneous group of disorders characterized by dysregulation of the immune system. Currently, no mechanisms have been demonstrated that could explain the correlation between vaccination and the development of autoimmune diseases. Furthermore, epidemiological studies do not support the hypothesis that vaccines cause systemic autoimmune diseases. The only confirmed associations, although very rare, are those between the flu vaccine and Guillain-Barré syndrome, especially with old vaccine preparations, and measles-mumps-rubella (MMR) vaccine and thrombocytopenia. Due to the SARS-CoV2 pandemic, new types of vaccines have been developed and are now available. Close vaccine safety-surveillance is currently underway for these new vaccines.