Fluorescence in situ hybridization detection of chromosome 7 and/or 17 polysomy as a prognostic marker for cholangiocarcinoma

Cholangiocarcinoma (CCA) is highly endemic in the Northeast Thailand. Recently, chromosome aberrations provided new insights into pathogenesis of CCA. Therefore, chromosome aberration might be used as a prognostic factor and therapeutic planning of this cancer. This aim of this study is to examine t...

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Bibliographic Details
Published in:Scientific reports 2022-05, Vol.12 (1), p.8441-8441, Article 8441
Main Authors: Deenonpoe, Raksawan, Sa-ngiamwibool, Prakasit, Watcharadetwittaya, Sasithorn, Thanee, Malinee, Intuyod, Kitti, Kongpan, Thachanan, Padthaisong, Sureerat, Nutalai, Rungtiwa, Chamgramol, Yaovalux, Pairojkul, Chawalit
Format: Article
Language:English
Subjects:
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Cholangiocarcinoma
Chromosome 7
Chromosome aberrations
Chromosomes
Copy number
Fluorescence
Fluorescence in situ hybridization
Humanities and Social Sciences
Hybridization
Lymph nodes
Metastases
multidisciplinary
Paraffin
Science
Science (multidisciplinary)
Trisomy
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Summary:Cholangiocarcinoma (CCA) is highly endemic in the Northeast Thailand. Recently, chromosome aberrations provided new insights into pathogenesis of CCA. Therefore, chromosome aberration might be used as a prognostic factor and therapeutic planning of this cancer. This aim of this study is to examine the correlation between an increase of chromosome 7 (C7) and/or 17 (C17) copy number variants (CNVs) with clinicopathological data and the overall survival time (OS) of CCA patients using fluorescence in situ hybridization (FISH) assays. C7 and C17 CNVs were examined using FISH form 157 formalin-fixed paraffin-embedded (FFPE) tissues of CCA patients from Khon Kaen, Thailand between 2011 and 2015. OS was visualized using Kaplan–Meier plot. Univariate and multivariate analyses were used to determine the ability of the clinicopathological parameters to predict OS. C17 > trisomy (odd ratio, 6.944, P   trisomy (odd ratio; 6.723, P   trisomy was independently correlated with short median OS. An increased of C7 and/or 17 have a potential as a poor prognostic marker in CCA patients.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-11945-8