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Fluorescence in situ hybridization detection of chromosome 7 and/or 17 polysomy as a prognostic marker for cholangiocarcinoma
Cholangiocarcinoma (CCA) is highly endemic in the Northeast Thailand. Recently, chromosome aberrations provided new insights into pathogenesis of CCA. Therefore, chromosome aberration might be used as a prognostic factor and therapeutic planning of this cancer. This aim of this study is to examine t...
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| Published in: | Scientific reports 2022-05, Vol.12 (1), p.8441-8441, Article 8441 |
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| creator | Deenonpoe, Raksawan Sa-ngiamwibool, Prakasit Watcharadetwittaya, Sasithorn Thanee, Malinee Intuyod, Kitti Kongpan, Thachanan Padthaisong, Sureerat Nutalai, Rungtiwa Chamgramol, Yaovalux Pairojkul, Chawalit |
| description | Cholangiocarcinoma (CCA) is highly endemic in the Northeast Thailand. Recently, chromosome aberrations provided new insights into pathogenesis of CCA. Therefore, chromosome aberration might be used as a prognostic factor and therapeutic planning of this cancer. This aim of this study is to examine the correlation between an increase of chromosome 7 (C7) and/or 17 (C17) copy number variants (CNVs) with clinicopathological data and the overall survival time (OS) of CCA patients using fluorescence in situ hybridization (FISH) assays. C7 and C17 CNVs were examined using FISH form 157 formalin-fixed paraffin-embedded (FFPE) tissues of CCA patients from Khon Kaen, Thailand between 2011 and 2015. OS was visualized using Kaplan–Meier plot. Univariate and multivariate analyses were used to determine the ability of the clinicopathological parameters to predict OS. C17 > trisomy (odd ratio, 6.944,
P
trisomy (odd ratio; 6.723,
P
trisomy was independently correlated with short median OS. An increased of C7 and/or 17 have a potential as a poor prognostic marker in CCA patients. |
| doi_str_mv | 10.1038/s41598-022-11945-8 |
| format | article |
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P
<
0.001
), C7/17 trisomy (odd ratio; 4.488,
P
=
0.019
), and C7/17 > trisomy (odd ratio; 6.723,
P
<
0.001
) were independently predictive factors for lymph node metastasis. Interestingly, an increase of C7, C17, and C7/17 CNVs in both trisomy and > trisomy was independently correlated with short median OS. An increased of C7 and/or 17 have a potential as a poor prognostic marker in CCA patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-022-11945-8</identifier><identifier>PMID: 35589822</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208 ; 631/337 ; 631/67 ; 692/308 ; 692/4017 ; 692/4020 ; 692/4028 ; 692/420 ; Cholangiocarcinoma ; Chromosome 7 ; Chromosome aberrations ; Chromosomes ; Copy number ; Fluorescence ; Fluorescence in situ hybridization ; Humanities and Social Sciences ; Hybridization ; Lymph nodes ; Metastases ; multidisciplinary ; Paraffin ; Science ; Science (multidisciplinary) ; Trisomy</subject><ispartof>Scientific reports, 2022-05, Vol.12 (1), p.8441-8441, Article 8441</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4558-b97a91eb771181fc537971f3c2fe34031919d76374ea3669dadc63112d82b5f33</citedby><cites>FETCH-LOGICAL-c4558-b97a91eb771181fc537971f3c2fe34031919d76374ea3669dadc63112d82b5f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2666720664/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2666720664?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35589822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deenonpoe, Raksawan</creatorcontrib><creatorcontrib>Sa-ngiamwibool, Prakasit</creatorcontrib><creatorcontrib>Watcharadetwittaya, Sasithorn</creatorcontrib><creatorcontrib>Thanee, Malinee</creatorcontrib><creatorcontrib>Intuyod, Kitti</creatorcontrib><creatorcontrib>Kongpan, Thachanan</creatorcontrib><creatorcontrib>Padthaisong, Sureerat</creatorcontrib><creatorcontrib>Nutalai, Rungtiwa</creatorcontrib><creatorcontrib>Chamgramol, Yaovalux</creatorcontrib><creatorcontrib>Pairojkul, Chawalit</creatorcontrib><title>Fluorescence in situ hybridization detection of chromosome 7 and/or 17 polysomy as a prognostic marker for cholangiocarcinoma</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Cholangiocarcinoma (CCA) is highly endemic in the Northeast Thailand. Recently, chromosome aberrations provided new insights into pathogenesis of CCA. Therefore, chromosome aberration might be used as a prognostic factor and therapeutic planning of this cancer. This aim of this study is to examine the correlation between an increase of chromosome 7 (C7) and/or 17 (C17) copy number variants (CNVs) with clinicopathological data and the overall survival time (OS) of CCA patients using fluorescence in situ hybridization (FISH) assays. C7 and C17 CNVs were examined using FISH form 157 formalin-fixed paraffin-embedded (FFPE) tissues of CCA patients from Khon Kaen, Thailand between 2011 and 2015. OS was visualized using Kaplan–Meier plot. Univariate and multivariate analyses were used to determine the ability of the clinicopathological parameters to predict OS. C17 > trisomy (odd ratio, 6.944,
P
<
0.001
), C7/17 trisomy (odd ratio; 4.488,
P
=
0.019
), and C7/17 > trisomy (odd ratio; 6.723,
P
<
0.001
) were independently predictive factors for lymph node metastasis. Interestingly, an increase of C7, C17, and C7/17 CNVs in both trisomy and > trisomy was independently correlated with short median OS. An increased of C7 and/or 17 have a potential as a poor prognostic marker in CCA patients.</description><subject>631/208</subject><subject>631/337</subject><subject>631/67</subject><subject>692/308</subject><subject>692/4017</subject><subject>692/4020</subject><subject>692/4028</subject><subject>692/420</subject><subject>Cholangiocarcinoma</subject><subject>Chromosome 7</subject><subject>Chromosome aberrations</subject><subject>Chromosomes</subject><subject>Copy number</subject><subject>Fluorescence</subject><subject>Fluorescence in situ hybridization</subject><subject>Humanities and Social Sciences</subject><subject>Hybridization</subject><subject>Lymph nodes</subject><subject>Metastases</subject><subject>multidisciplinary</subject><subject>Paraffin</subject><subject>Science</subject><subject>Science 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Rep</addtitle><date>2022-05-19</date><risdate>2022</risdate><volume>12</volume><issue>1</issue><spage>8441</spage><epage>8441</epage><pages>8441-8441</pages><artnum>8441</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Cholangiocarcinoma (CCA) is highly endemic in the Northeast Thailand. Recently, chromosome aberrations provided new insights into pathogenesis of CCA. Therefore, chromosome aberration might be used as a prognostic factor and therapeutic planning of this cancer. This aim of this study is to examine the correlation between an increase of chromosome 7 (C7) and/or 17 (C17) copy number variants (CNVs) with clinicopathological data and the overall survival time (OS) of CCA patients using fluorescence in situ hybridization (FISH) assays. C7 and C17 CNVs were examined using FISH form 157 formalin-fixed paraffin-embedded (FFPE) tissues of CCA patients from Khon Kaen, Thailand between 2011 and 2015. OS was visualized using Kaplan–Meier plot. Univariate and multivariate analyses were used to determine the ability of the clinicopathological parameters to predict OS. C17 > trisomy (odd ratio, 6.944,
P
<
0.001
), C7/17 trisomy (odd ratio; 4.488,
P
=
0.019
), and C7/17 > trisomy (odd ratio; 6.723,
P
<
0.001
) were independently predictive factors for lymph node metastasis. Interestingly, an increase of C7, C17, and C7/17 CNVs in both trisomy and > trisomy was independently correlated with short median OS. An increased of C7 and/or 17 have a potential as a poor prognostic marker in CCA patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35589822</pmid><doi>10.1038/s41598-022-11945-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2022-05, Vol.12 (1), p.8441-8441, Article 8441 |
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| language | eng |
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| source | Open Access: PubMed Central; Publicly Available Content Database; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/208 631/337 631/67 692/308 692/4017 692/4020 692/4028 692/420 Cholangiocarcinoma Chromosome 7 Chromosome aberrations Chromosomes Copy number Fluorescence Fluorescence in situ hybridization Humanities and Social Sciences Hybridization Lymph nodes Metastases multidisciplinary Paraffin Science Science (multidisciplinary) Trisomy |
| title | Fluorescence in situ hybridization detection of chromosome 7 and/or 17 polysomy as a prognostic marker for cholangiocarcinoma |
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